DNA Traits · Skin & sun
Stretch marks
Whether people report having stretch marks on their skin.
What the research found
In the cited research, the T allele at rs7787362 was associated with a lower chance of reporting stretch marks in the studied cohort.
- CC
- More often
- CT
- Middle
- TT
- Less often
- Evidence
- Genome-wide association with replication in an independent pregnancy cohort
- Who was studied
- 23andMe research participants of European ancestry (women and men)
How common each genotype is
| Region | CCMore often | CTMiddle | TTLess often |
|---|---|---|---|
| All regions2,504 people | 11% | 36% | 53% |
| Africa661 people | <1% | 17% | 82% |
| The Americas347 people | 14% | 43% | 44% |
| East Asia504 people | 5% | 36% | 59% |
| Europe503 people | 30% | 47% | 23% |
| South Asia489 people | 11% | 43% | 46% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 63%41 of 65 copies read |
|---|---|
| First farmers6500 to 3000 BC | 48%490 of 1,026 copies read |
| Bronze Age3000 to 1200 BC | 45%448 of 992 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 50%614 of 1,219 copies read |
| Middle AgesAD 600 to 1500 | 52%317 of 609 copies read |
| Today1000 Genomes | 46%464 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- Near ELN
- Marker
- rs7787362
- Location
- Chromosome 7 · GRCh37 73,392,603 · GRCh38 73,978,273
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- Near ELN · rs7787362
- Location
- Chromosome 7 · GRCh37 73,392,603 · GRCh38 73,978,273
- Studied allele
- T
- Published statistic
- OR 0.84 (0.81 to 0.87) per T (minor allele), P 1.8e-23, MAF 0.467 (discovery, Table 1); disjoint pregnancy cohort of 4,967 women: P 7e-5, beta 0.072 (0.053 to 0.091) per C (major allele) on stretch-mark severity (Table 1) (Table 1)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 283 / 892 / 1329 · Africa 5 / 114 / 542 · The Americas 48 / 148 / 151 · East Asia 23 / 183 / 298 · Europe 153 / 236 / 114 · South Asia 54 / 211 / 224
What it cannot tell you
Stretch marks were self-reported, and women reported them more than twice as often as men (55% versus 25%).
Genome-wide association analysis implicates elastic microfibrils in the development of nonsyndromic striae distensae (Tung et al., 2013)More in Skin & sun
- Ease of tanning association
- Severe sunburn history association
- Mole count association
- Facial pigmented spots association
- Ease of tanning (TYRP1)
- Ease of tanning (TRPS1)
- Ease of tanning (EMX2)
- Ease of tanning (IRF4)
- Ease of tanning (SPIRE2)
- Ease of tanning (MC1R R151C)
- Tanning ability (ASIP region)
- Ease of sunburn (SLC45A2)
- Sunburn history (MC1R R160W)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.