DNA Traits · Skin & sun
Ease of tanning (TYRP1)
How easily skin tans in the sun.
What the research found
In the cited research, the T allele at rs1326797 was associated with greater self-reported ease of skin tanning in the studied cohorts.
- GG
- Tans less
- GT
- Middle
- TT
- Tans more
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry UK Biobank participants and five independent European-ancestry replication cohorts
How common each genotype is
| Region | GGTans less | GTMiddle | TTTans more |
|---|---|---|---|
| All regions2,504 people | 11% | 25% | 65% |
| Africa661 people | <1% | 11% | 89% |
| The Americas347 people | 16% | 45% | 39% |
| East Asia504 people | Not seen | 4% | 96% |
| Europe503 people | 37% | 46% | 17% |
| South Asia489 people | 6% | 29% | 65% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- TYRP1
- Marker
- rs1326797
- Location
- Chromosome 9 · GRCh37 12,716,762 · GRCh38 12,716,763
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- TYRP1 · rs1326797
- Location
- Chromosome 9 · GRCh37 12,716,762 · GRCh38 12,716,763
- Studied allele
- T
- Published statistic
- OR 0.93 per T allele for low tan response (95 per cent CI 0.91 to 0.94, SE 0.01), UK Biobank discovery P 1.24e-17, n 121,296; replication meta-analysis in five European cohorts (n 55,382) P 2.62e-11 (Table 1); the same T allele goes with darker non-red hair, beta 0.035 (0.029 to 0.040) on a one to three scale, P 1.35e-32 (Supplementary Table 16) (Results, first paragraph of Genome-wide association analyses (the 121,296 figure) and Table 1 with its footnote (the odds ratio))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 272 / 615 / 1617 · Africa 2 / 72 / 587 · The Americas 54 / 156 / 137 · East Asia 0 / 18 / 486 · Europe 186 / 229 / 88 · South Asia 30 / 140 / 319
What it cannot tell you
Studied in European ancestry only; outside Europe almost everyone carries two copies of the studied letter.
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure (Visconti et al., 2018)More in Skin & sun
- Ease of tanning association
- Severe sunburn history association
- Mole count association
- Facial pigmented spots association
- Ease of tanning (TRPS1)
- Ease of tanning (EMX2)
- Ease of tanning (IRF4)
- Ease of tanning (SPIRE2)
- Ease of tanning (MC1R R151C)
- Tanning ability (ASIP region)
- Ease of sunburn (SLC45A2)
- Sunburn history (MC1R R160W)
- Stretch marks
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.