DNA Traits · Skin & sun
Ease of tanning association
How easily skin tans in the sun.
What the research found
In the cited research, the C allele at rs10810650 was associated with greater self-reported ease of skin tanning in the studied cohorts.
- TT
- Tans less
- CT
- Middle
- CC
- Tans more
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry UK Biobank participants and five independent European-ancestry replication cohorts
How common each genotype is
| Region | TTTans less | CTMiddle | CCTans more |
|---|---|---|---|
| All regions2,504 people | 11% | 36% | 52% |
| Africa661 people | 2% | 25% | 73% |
| The Americas347 people | 14% | 45% | 41% |
| East Asia504 people | 7% | 40% | 53% |
| Europe503 people | 35% | 48% | 18% |
| South Asia489 people | 3% | 31% | 66% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- BNC2
- Marker
- rs10810650
- Location
- Chromosome 9 · GRCh37 16,873,551 · GRCh38 16,873,553
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- BNC2 · rs10810650
- Location
- Chromosome 9 · GRCh37 16,873,551 · GRCh38 16,873,553
- Studied allele
- C
- Published statistic
- OR 0.87 per C allele for low tan response (95% CI 0.85 to 0.88, SE 0.01), UK Biobank discovery P 2.38e-59; replication meta-analysis in five European cohorts (n 55,382) P 2.10e-29 (Table 1) (Table 1 and its footnote)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 287 / 910 / 1307 · Africa 12 / 164 / 485 · The Americas 49 / 156 / 142 · East Asia 34 / 201 / 269 · Europe 175 / 239 / 89 · South Asia 17 / 150 / 322
What it cannot tell you
The study compared questionnaire categories of ease of tanning. This marker cannot tell you how your skin will react to sun exposure, give a safe UV dose, show protection from sun damage or predict skin cancer. Only the studied C/T allele pair is interpreted.
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure (Visconti et al., 2018)More in Skin & sun
- Severe sunburn history association
- Mole count association
- Facial pigmented spots association
- Ease of tanning (TYRP1)
- Ease of tanning (TRPS1)
- Ease of tanning (EMX2)
- Ease of tanning (IRF4)
- Ease of tanning (SPIRE2)
- Ease of tanning (MC1R R151C)
- Tanning ability (ASIP region)
- Ease of sunburn (SLC45A2)
- Sunburn history (MC1R R160W)
- Stretch marks
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.