DNA Traits · Skin & sun
Severe sunburn history association
How many severe sunburns people recall having had.
What the research found
In the cited research, the A allele at rs1126809 was associated with a greater self-reported lifetime number of severe sunburns in the studied cohorts.
- GG
- Fewer burns
- AG
- Middle
- AA
- More burns
- Evidence
- Genome-wide association in a multi-cohort study
- Who was studied
- European-American participants from the Nurses’ Health Study and Health Professionals Follow-up Study
How common each genotype is
| Region | GGFewer burns | AGMiddle | AAMore burns |
|---|---|---|---|
| All regions2,504 people | 85% | 14% | 1% |
| Africa661 people | 98% | 1% | <1% |
| The Americas347 people | 76% | 23% | 1% |
| East Asia504 people | >99% | <1% | Not seen |
| Europe503 people | 54% | 41% | 5% |
| South Asia489 people | 90% | 10% | <1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 1%1 of 67 copies read |
|---|---|
| First farmers6500 to 3000 BC | 8%69 of 862 copies read |
| Bronze Age3000 to 1200 BC | 18%134 of 751 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 21%212 of 990 copies read |
| Middle AgesAD 600 to 1500 | 18%95 of 537 copies read |
| Today1000 Genomes | 25%254 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- Not read
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- TYR
- Marker
- rs1126809
- Location
- Chromosome 11 · GRCh37 89,017,961 · GRCh38 89,284,793
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- TYR · rs1126809
- Location
- Chromosome 11 · GRCh37 89,017,961 · GRCh38 89,284,793
- Studied allele
- A
- Published statistic
- beta 0.60 (SE 0.11) per A allele (reference G) on the number of lifetime severe sunburns, face, limbs and back combined and coded as a continuous variable, P 1.8e-8 (Table 6); the same A allele lowers tanning ability (beta -0.12, P 5.0e-21, Table 6) (Table 6 (rs1126809, number of sunburns column) and Methods)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2130 / 341 / 33 · Africa 651 / 8 / 2 · The Americas 264 / 79 / 4 · East Asia 503 / 1 / 0 · Europe 274 / 204 / 25 · South Asia 438 / 49 / 2
What it cannot tell you
The measured outcome was questionnaire-reported lifetime severe sunburns on the face, limbs and back, which also depends on sun exposure and behaviour. This is not a direct skin reaction test, a safe UV-dose estimate, a prediction of skin cancer or protection from sun damage. Only the studied A/G allele pair is interpreted.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans (Zhang et al., 2013)More in Skin & sun
- Ease of tanning association
- Mole count association
- Facial pigmented spots association
- Ease of tanning (TYRP1)
- Ease of tanning (TRPS1)
- Ease of tanning (EMX2)
- Ease of tanning (IRF4)
- Ease of tanning (SPIRE2)
- Ease of tanning (MC1R R151C)
- Tanning ability (ASIP region)
- Ease of sunburn (SLC45A2)
- Sunburn history (MC1R R160W)
- Stretch marks
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.