DNA Traits · Immune biology
Basophil count association
The number of basophils, a rare white blood cell, in the blood.
What the research found
In the cited research, the A allele at rs4328821 was associated with higher basophil counts in the studied cohorts.
- GG
- Lower average
- AG
- Middle
- AA
- Higher average
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry discovery and independent replication cohorts
How common each genotype is
| Region | GGLower average | AGMiddle | AAHigher average |
|---|---|---|---|
| All regions2,504 people | 5% | 29% | 66% |
| Africa661 people | 2% | 23% | 75% |
| The Americas347 people | 3% | 28% | 69% |
| East Asia504 people | 14% | 43% | 43% |
| Europe503 people | <1% | 19% | 80% |
| South Asia489 people | 4% | 34% | 62% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 95%57 of 60 copies read |
|---|---|
| First farmers6500 to 3000 BC | 94%867 of 919 copies read |
| Bronze Age3000 to 1200 BC | 90%728 of 810 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 89%951 of 1,072 copies read |
| Middle AgesAD 600 to 1500 | 87%478 of 549 copies read |
| Today1000 Genomes | 90%903 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- RPN1 region
- Marker
- rs4328821
- Location
- Chromosome 3 · GRCh37 128,316,435 · GRCh38 128,597,592
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- RPN1 region · rs4328821
- Location
- Chromosome 3 · GRCh37 128,316,435 · GRCh38 128,597,592
- Studied allele
- A
- Published statistic
- Joint beta +0.010 per A allele on square-root basophil count (SE 0.001), P 8.72e-13; discovery +0.010 (SE 0.002), P 2.58e-8; independent replication +0.010 (SE 0.002), P 8.40e-6 (Table 2) (Table 2, basophil count row; Methods (transformation))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 117 / 731 / 1656 · Africa 12 / 154 / 495 · The Americas 10 / 96 / 241 · East Asia 72 / 217 / 215 · Europe 3 / 97 / 403 · South Asia 20 / 167 / 302
What it cannot tell you
This small association is with a laboratory blood-cell count within the normal range studied. It does not estimate your current count, grade immune strength or predict infection, allergy, autoimmune disease or blood cancer. Only the studied A/G allele pair is interpreted.
Multiple Loci Are Associated with White Blood Cell Phenotypes (Nalls et al., 2011)More in Immune biology
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.