DNA Traits · Immune biology

C-reactive protein level

The blood level of C-reactive protein, a protein made by the liver.

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Evidence · Replicated

What the research found

In the cited research, the C allele at rs2794520 was associated with higher circulating C-reactive protein concentrations in the studied cohorts.

TT: Lower average
CT: Middle
CC: Higher average

Modest effect

Evidence: Genome-wide association with independent replication
Who was studied: European-ancestry discovery and replication cohorts

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	TTLower average	CTMiddle	CCHigher average
All regions2,504 people	13%	42%	45%
Africa661 people	3%	31%	66%
The Americas347 people	14%	48%	38%
East Asia504 people	32%	49%	19%
Europe503 people	11%	40%	49%
South Asia489 people	10%	46%	44%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	39%22 of 56 copies read
First farmers6500 to 3000 BC	59%506 of 853 copies read
Bronze Age3000 to 1200 BC	62%479 of 775 copies read
Iron Age and Antiquity1200 BC to AD 600	63%651 of 1,041 copies read
Middle AgesAD 600 to 1500	57%326 of 572 copies read
Today1000 Genomes	69%693 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: 2 copies
Chagyrskaya Neanderthal: 2 copies
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs2794520

The marker

Gene or region: CRP
Marker: rs2794520
Location: Chromosome 1 · GRCh37 159,678,816 · GRCh38 159,709,026
Letters studied: C and T, with C as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: CRP · rs2794520
Location: Chromosome 1 · GRCh37 159,678,816 · GRCh38 159,709,026
Studied allele: C
Published statistic: Discovery beta 0.193 on ln CRP (mg/L) per C (SE 0.007), P 9.5e-189, N 66,185, coded allele frequency 0.66 (Table 1); replication 0.086 (0.010), P 9.9e-19, N 16,540; combined 0.160 (0.006), P 2.0e-186, median R2 1.38%, heterogeneity P 7.4e-26 (Table 2). Ligthart 2018: 0.182 per C, P 4.17e-523, R2 0.014 (Results, Methods) (Tables 1 and 2)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 335 / 1043 / 1126 · Africa 19 / 204 / 438 · The Americas 49 / 165 / 133 · East Asia 162 / 246 / 96 · Europe 55 / 203 / 245 · South Asia 50 / 225 / 214

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Limits

What it cannot tell you

CRP rises sharply during infections and other short-lived inflammation, which outweighs this marker on any given day.

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels (Dehghan et al., 2011)

The same topic

More in Immune biology

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