DNA Traits · Immune biology
Total IgE concentration association
The blood level of IgE, the antibody involved in allergic reactions.
What the research found
In the cited research, the C allele at rs2251746 was associated with lower total serum IgE concentrations in the studied cohorts.
- TT
- Higher average
- CT
- Middle
- CC
- Lower average
What the study found
In the study, each copy went with total IgE in blood about 19.2% lower on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- German population cohorts of adults and children
How common each genotype is
| Region | TTHigher average | CTMiddle | CCLower average |
|---|---|---|---|
| All regions2,504 people | 74% | 22% | 4% |
| Africa661 people | 91% | 9% | <1% |
| The Americas347 people | 74% | 24% | 3% |
| East Asia504 people | 91% | 9% | <1% |
| Europe503 people | 50% | 40% | 10% |
| South Asia489 people | 58% | 33% | 9% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 45%17 of 38 copies read |
|---|---|
| First farmers6500 to 3000 BC | 26%114 of 441 copies read |
| Bronze Age3000 to 1200 BC | 31%98 of 316 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 25%109 of 435 copies read |
| Middle AgesAD 600 to 1500 | 27%98 of 369 copies read |
| Today1000 Genomes | 30%298 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- FCER1A
- Marker
- rs2251746
- Location
- Chromosome 1 · GRCh37 159,272,060 · GRCh38 159,302,270
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FCER1A · rs2251746
- Location
- Chromosome 1 · GRCh37 159,272,060 · GRCh38 159,302,270
- Studied allele
- C
- Published statistic
- Combined replication beta -0.213 per C allele on log IgE, P 1.85e-20, -19.21% per C allele, N 9,769; KORA S4 -0.227 (P 6.07e-10), GINI -0.236 (P 8.14e-6), LISA -0.290 (P 4.18e-5), ISAAC -0.153 (P 2.11e-4) (Table 1). Framingham: minor C beta -0.084 on log10 IgE, P 2.11e-12 (PMC3293994, Table 2) (Table 1, rs2251746 row, Combined columns (Est. %); Methods (percent-change model))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1858 / 545 / 101 · Africa 603 / 57 / 1 · The Americas 256 / 82 / 9 · East Asia 460 / 43 / 1 · Europe 253 / 202 / 48 · South Asia 286 / 161 / 42
What it cannot tell you
The association concerns total IgE measured in blood. It does not estimate your current IgE, identify an allergen, test for allergy or asthma, or indicate whether your immune system is stronger or weaker. Only the studied C/T allele pair is interpreted.
Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus (Weidinger et al., 2008)More in Immune biology
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.