DNA Traits · Immune biology
Monocyte count association
The number of monocytes, a type of white blood cell, in the blood.
What the research found
In the cited research, the T allele at rs1449263 was associated with higher monocyte counts in the studied cohorts.
- CC
- Lower average
- CT
- Middle
- TT
- Higher average
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry discovery and independent replication cohorts
How common each genotype is
| Region | CCLower average | CTMiddle | TTHigher average |
|---|---|---|---|
| All regions2,504 people | 23% | 46% | 30% |
| Africa661 people | 15% | 48% | 36% |
| The Americas347 people | 24% | 48% | 29% |
| East Asia504 people | 42% | 42% | 16% |
| Europe503 people | 22% | 49% | 29% |
| South Asia489 people | 16% | 45% | 40% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 35%19 of 54 copies read |
|---|---|
| First farmers6500 to 3000 BC | 50%360 of 714 copies read |
| Bronze Age3000 to 1200 BC | 55%329 of 601 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 51%429 of 847 copies read |
| Middle AgesAD 600 to 1500 | 48%263 of 544 copies read |
| Today1000 Genomes | 54%540 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- ITGA4 region
- Marker
- rs1449263
- Location
- Chromosome 2 · GRCh37 182,319,301 · GRCh38 181,454,574
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- ITGA4 region · rs1449263
- Location
- Chromosome 2 · GRCh37 182,319,301 · GRCh38 181,454,574
- Studied allele
- T
- Published statistic
- Joint beta +0.036 per T allele on natural-log monocyte count (SE 0.004), P 5.21e-23; discovery +0.036 (SE 0.005), P 6.71e-14; independent replication +0.037 (SE 0.006), P 2.13e-10 (Table 2) (Table 2, monocyte count row; Methods (transformation))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 584 / 1157 / 763 · Africa 101 / 320 / 240 · The Americas 82 / 165 / 100 · East Asia 214 / 210 / 80 · Europe 111 / 244 / 148 · South Asia 76 / 218 / 195
What it cannot tell you
This small association is with a laboratory blood-cell count within the normal range studied. It does not estimate your current count, grade immune strength or predict infection, allergy, autoimmune disease or blood cancer. Only the studied C/T allele pair is interpreted.
Multiple Loci Are Associated with White Blood Cell Phenotypes (Nalls et al., 2011)More in Immune biology
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.