DNA Traits · Immune biology
IL-6 receptor level
The blood level of the soluble receptor for interleukin-6, a protein used in immune signalling.
What the research found
In the cited research, the T allele at rs4129267 was associated with higher circulating soluble interleukin-6 receptor concentrations in the studied cohorts.
- CC
- Lower average
- CT
- Middle
- TT
- Higher average
What the study found
In the study, the average blood level of this receptor, by genotype:
- CCNo copy
- 69.9 ng/mL
- CTOne copy
- 100.7 ng/mL
- TTTwo copies
- 138.1 ng/mL
- Evidence
- Genome-wide protein association, replicated in later protein studies
- Who was studied
- Italian adults (InCHIANTI), confirmed in later European protein studies
How common each genotype is
| Region | CCLower average | CTMiddle | TTHigher average |
|---|---|---|---|
| All regions2,504 people | 52% | 38% | 11% |
| Africa661 people | 83% | 16% | <1% |
| The Americas347 people | 21% | 50% | 29% |
| East Asia504 people | 46% | 43% | 11% |
| Europe503 people | 41% | 45% | 13% |
| South Asia489 people | 48% | 43% | 8% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 30%19 of 63 copies read |
|---|---|
| First farmers6500 to 3000 BC | 47%447 of 943 copies read |
| Bronze Age3000 to 1200 BC | 46%389 of 844 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 37%404 of 1,093 copies read |
| Middle AgesAD 600 to 1500 | 41%237 of 583 copies read |
| Today1000 Genomes | 36%362 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- IL6R
- Marker
- rs4129267
- Location
- Chromosome 1 · GRCh37 154,426,264 · GRCh38 154,453,788
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- IL6R · rs4129267
- Location
- Chromosome 1 · GRCh37 154,426,264 · GRCh38 154,453,788
- Studied allele
- T
- Published statistic
- IL-6sR back-transformed means (95% CI) 69.92 (66.95 to 72.99), 100.65 (96.97 to 104.44), 138.13 (129.94 to 146.77) ng/mL for common homozygote, heterozygote, minor homozygote; MAF 0.37; P 1.82e-57; permutation P < 0.00001 (Table 2); 0.69 SD per allele (Results). Sun 2018: T +1.1, P reported as 0; Suhre 2017: +1.208, P 2e-265 (GWAS Catalog) (Table 2 (IL-6sR row); N from Table S1 (sIL-6r row))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1298 / 941 / 265 · Africa 547 / 109 / 5 · The Americas 74 / 174 / 99 · East Asia 232 / 219 / 53 · Europe 208 / 228 / 67 · South Asia 237 / 211 / 41
What it cannot tell you
The marker raises the soluble receptor by changing how the receptor is shed from cells; it does not measure interleukin-6 activity.
A genome-wide association study identifies protein quantitative trait loci (pQTLs) (Melzer et al., 2008)More in Immune biology
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.