DNA Traits · Immune biology
Neutrophil count association
The number of neutrophils, the most common white blood cell, in the blood.
What the research found
In the cited research, the T allele at rs8078723 was associated with lower neutrophil counts in the studied cohorts.
- CC
- Higher average
- CT
- Middle
- TT
- Lower average
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry discovery and independent replication cohorts
How common each genotype is
| Region | CCHigher average | CTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 12% | 44% | 44% |
| Africa661 people | 7% | 42% | 52% |
| The Americas347 people | 10% | 45% | 45% |
| East Asia504 people | 21% | 48% | 31% |
| Europe503 people | 16% | 45% | 40% |
| South Asia489 people | 7% | 41% | 52% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 57%35 of 61 copies read |
|---|---|
| First farmers6500 to 3000 BC | 71%629 of 887 copies read |
| Bronze Age3000 to 1200 BC | 63%506 of 803 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 66%705 of 1,065 copies read |
| Middle AgesAD 600 to 1500 | 62%368 of 597 copies read |
| Today1000 Genomes | 62%625 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- Not read
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- ORMDL3 / CSF3 region
- Marker
- rs8078723
- Location
- Chromosome 17 · GRCh37 38,166,879 · GRCh38 40,010,626
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- ORMDL3 / CSF3 region · rs8078723
- Location
- Chromosome 17 · GRCh37 38,166,879 · GRCh38 40,010,626
- Studied allele
- T
- Published statistic
- Joint beta -0.041 per T allele on natural-log neutrophil count (SE 0.004), P 3.16e-31; discovery -0.043 (SE 0.004), P 2.84e-23; independent replication -0.036 (SE 0.006), P 4.99e-10 (Table 2) (Table 2, neutrophil count row; Methods (transformation))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 296 / 1099 / 1109 · Africa 44 / 275 / 342 · The Americas 35 / 156 / 156 · East Asia 105 / 243 / 156 · Europe 78 / 225 / 200 · South Asia 34 / 200 / 255
What it cannot tell you
This small association is with a laboratory blood-cell count within the normal range studied. It does not estimate your current count, grade immune strength or predict infection, allergy, autoimmune disease or blood cancer. Only the studied C/T allele pair is interpreted.
Multiple Loci Are Associated with White Blood Cell Phenotypes (Nalls et al., 2011)More in Immune biology
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.