DNA Traits · Mind & behaviour
Agreeableness questionnaire research association
A questionnaire score for how cooperative and trusting people describe themselves.
What the research found
In the cited research, the T allele at rs17137124 was associated with higher agreeableness questionnaire scores in the studied cohorts.
- CC
- Lower score
- CT
- Middle
- TT
- Higher score
- Evidence
- Limited discovery GWAS evidence
- Who was studied
- European-ancestry multi-cohort analyses including the US Million Veteran Program; the MVP component was predominantly older men
How common each genotype is
| Region | CCLower score | CTMiddle | TTHigher score |
|---|---|---|---|
| All regions2,504 people | 30% | 43% | 27% |
| Africa661 people | 7% | 37% | 56% |
| The Americas347 people | 33% | 48% | 20% |
| East Asia504 people | 56% | 38% | 7% |
| Europe503 people | 28% | 50% | 22% |
| South Asia489 people | 36% | 48% | 16% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 43%12 of 28 copies read |
|---|---|
| First farmers6500 to 3000 BC | 70%152 of 218 copies read |
| Bronze Age3000 to 1200 BC | 61%79 of 129 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 57%140 of 244 copies read |
| Middle AgesAD 600 to 1500 | 48%123 of 258 copies read |
| Today1000 Genomes | 47%472 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- Not read
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- Not read
- Denisovan
- Not read
The marker
- Gene or region
- FOXP2 region
- Marker
- rs17137124
- Location
- Chromosome 7 · GRCh37 114,210,814 · GRCh38 114,570,759
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FOXP2 region · rs17137124
- Location
- Chromosome 7 · GRCh37 114,210,814 · GRCh38 114,570,759
- Studied allele
- T
- Published statistic
- beta +0.0327 per T allele (SE 0.0052; the paper states no unit or standardisation), P 3.99e-10, T frequency 0.4568, locus marked 'Novel' (Supplementary Table 8, EUR meta-analysis of MVP with GPC phase 1) (Supplementary Table 8, rs17137124 row)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 757 / 1083 / 664 · Africa 44 / 244 / 373 · The Americas 114 / 165 / 68 · East Asia 282 / 189 / 33 · Europe 142 / 250 / 111 · South Asia 175 / 235 / 79
What it cannot tell you
This small association concerns scores on self-reported personality questionnaires. A single marker cannot assess your personality, emotional state, intelligence, capability or mental health. It gives no personality score and says nothing about any mental-health condition. The agreeableness and conscientiousness cards use nearby FOXP2-region markers, so their results are correlated rather than independent findings. Only the studied C/T allele pair is interpreted. Independent replication of this exact questionnaire association has not been verified; this card is a research finding.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology (Gupta et al., 2024)More in Mind & behaviour
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- Conscientiousness questionnaire research association
- Openness questionnaire research association
- Subjective well-being research association
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See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.