DNA Traits · Mind & behaviour
Neuroticism questionnaire association
A questionnaire score for the tendency to worry and feel negative emotions.
What the research found
In the cited research, the A allele at rs11090045 was associated with higher neuroticism questionnaire scores in the studied cohorts.
- GG
- Lower score
- AG
- Middle
- AA
- Higher score
- Evidence
- Multi-cohort GWAS at a previously reported locus
- Who was studied
- European-ancestry multi-cohort analyses including the US Million Veteran Program; the MVP component was predominantly older men
How common each genotype is
| Region | GGLower score | AGMiddle | AAHigher score |
|---|---|---|---|
| All regions2,504 people | 65% | 27% | 8% |
| Africa661 people | 96% | 4% | <1% |
| The Americas347 people | 31% | 50% | 19% |
| East Asia504 people | 92% | 8% | Not seen |
| Europe503 people | 48% | 43% | 10% |
| South Asia489 people | 39% | 44% | 17% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 7%2 of 29 copies read |
|---|---|
| First farmers6500 to 3000 BC | 21%51 of 247 copies read |
| Bronze Age3000 to 1200 BC | 38%57 of 149 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 31%87 of 282 copies read |
| Middle AgesAD 600 to 1500 | 29%69 of 236 copies read |
| Today1000 Genomes | 31%311 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- Not read
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- Not read
The marker
- Gene or region
- ZC3H7B region
- Marker
- rs11090045
- Location
- Chromosome 22 · GRCh37 41,753,603 · GRCh38 41,357,599
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- ZC3H7B region · rs11090045
- Location
- Chromosome 22 · GRCh37 41,753,603 · GRCh38 41,357,599
- Studied allele
- A
- Published statistic
- beta +0.0209 per A allele (SE 0.0024; the paper states no unit or standardisation), P 6.072e-18, A frequency 0.3023 (Supplementary Table 6, EUR meta-analysis of MVP with Nagel et al.) (Supplementary Table 6, rs11090045 row)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1636 / 670 / 198 · Africa 632 / 28 / 1 · The Americas 107 / 173 / 67 · East Asia 466 / 38 / 0 · Europe 240 / 215 / 48 · South Asia 191 / 216 / 82
What it cannot tell you
This small association concerns scores on self-reported personality questionnaires. A single marker cannot assess your personality, emotional state, intelligence, capability or mental health. It gives no personality score and says nothing about any mental-health condition. Only the studied A/G allele pair is interpreted.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology (Gupta et al., 2024)More in Mind & behaviour
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- Agreeableness questionnaire research association
- Conscientiousness questionnaire research association
- Openness questionnaire research association
- Subjective well-being research association
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- Hand preference, MAP2 marker
- Hand preference, FURIN marker
- Clapping in time to a beat
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.