DNA Traits · Mind & behaviour
Subjective well-being research association
A questionnaire score for how satisfied and happy people say they are.
What the research found
In the cited research, the A allele at rs3756290 was associated with lower subjective well-being questionnaire scores in the studied cohorts.
- GG
- Higher score
- AG
- Middle
- AA
- Lower score
What the study found
In the study, each copy went with lower well-being questionnaire score on average.
- Evidence
- Limited discovery GWAS evidence
- Who was studied
- European-ancestry adults across population cohorts
How common each genotype is
| Region | GGHigher score | AGMiddle | AALower score |
|---|---|---|---|
| All regions2,504 people | 30% | 38% | 33% |
| Africa661 people | 1% | 18% | 81% |
| The Americas347 people | 31% | 52% | 17% |
| East Asia504 people | 23% | 53% | 24% |
| Europe503 people | 55% | 36% | 9% |
| South Asia489 people | 48% | 42% | 11% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- RAPGEF6 region
- Marker
- rs3756290
- Location
- Chromosome 5 · GRCh37 130,951,750 · GRCh38 131,616,057
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- RAPGEF6 region · rs3756290
- Location
- Chromosome 5 · GRCh37 130,951,750 · GRCh38 131,616,057
- Studied allele
- A
- Published statistic
- beta -0.0177 SD per A allele (SE 0.0031), P 9.6e-9, R2 0.011%, N 286,851, A frequency 0.24 (Table 1); 0.02 SD per copy (Table 1, Panel A, rs3756290 row (effect sizes in SD units per allele, table note))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 741 / 946 / 817 · Africa 7 / 116 / 538 · The Americas 107 / 181 / 59 · East Asia 117 / 265 / 122 · Europe 276 / 181 / 46 · South Asia 234 / 203 / 52
What it cannot tell you
The study combined life-satisfaction and positive-affect questionnaires. This tiny population-level association cannot measure your happiness, life satisfaction or current mood, and does not predict depression or any other mental-health condition. Only the studied A/G allele pair is interpreted. Independent replication of this exact well-being association has not been verified; the reported discovery effect is not an individual happiness prediction.
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (Okbay et al., 2016)More in Mind & behaviour
- Neuroticism questionnaire association
- Extraversion questionnaire association
- Agreeableness questionnaire research association
- Conscientiousness questionnaire research association
- Openness questionnaire research association
- Hand preference, CRHR1 marker
- Hand preference, MAP2 marker
- Hand preference, FURIN marker
- Clapping in time to a beat
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.