DNA Traits · Mind & behaviour
Hand preference, MAP2 marker
Whether people are left-handed or right-handed.
What the research found
In the cited research, the A allele at rs62213410 was associated with a lower likelihood of being left-handed in the studied cohorts.
- TT
- More often
- AT
- Middle
- AA
- Less often
- Evidence
- Genome-wide meta-analysis of three cohorts, same direction in each
- Who was studied
- Primarily European ancestry
How common each genotype is
| Region | TTMore often | ATMiddle | AALess often |
|---|---|---|---|
| All regions2,504 people | 5% | 30% | 65% |
| Africa661 people | 5% | 31% | 65% |
| The Americas347 people | 4% | 39% | 57% |
| East Asia504 people | Not seen | 2% | 98% |
| Europe503 people | 7% | 42% | 52% |
| South Asia489 people | 9% | 41% | 50% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- MAP2
- Marker
- rs62213410
- Location
- Chromosome 2 · GRCh37 210,300,731 · GRCh38 209,436,007
- Letters studied
- A and T, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- MAP2 · rs62213410
- Location
- Chromosome 2 · GRCh37 210,300,731 · GRCh38 209,436,007
- Studied allele
- A
- Published statistic
- OR 0.96 per A allele for left- versus right-handedness (23andMe OR, Table 1 footnote a); meta-analysis Z -11.45, P 2.37e-30, the strongest left-handedness locus in the table; direction negative in 23andMe, UK Biobank and IHC; A frequency 0.71 (Table 1) (Table 1, rs62213410 row: OR from the 23andMe results (footnote a); Z, P and direction from the meta-analysis)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 122 / 759 / 1623 · Africa 30 / 204 / 427 · The Americas 15 / 135 / 197 · East Asia 0 / 12 / 492 · Europe 33 / 209 / 261 · South Asia 44 / 199 / 246
What it cannot tell you
Left-handedness was compared with right-handedness, and each copy shifts the odds only slightly. Only the studied A/T pair is read.
Genome-wide association study identifies 48 common genetic variants associated with handedness (Cuellar-Partida et al., 2021)More in Mind & behaviour
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See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.