DNA Traits · Mind & behaviour
Openness questionnaire research association
A questionnaire score for how curious and open to new ideas people describe themselves.
What the research found
In the cited research, the C allele at rs7570 was associated with lower openness questionnaire scores in the studied cohorts.
- GG
- Higher score
- CG
- Middle
- CC
- Lower score
- Evidence
- Limited discovery GWAS evidence
- Who was studied
- European-ancestry multi-cohort analyses including the US Million Veteran Program; the MVP component was predominantly older men
How common each genotype is
| Region | GGHigher score | CGMiddle | CCLower score |
|---|---|---|---|
| All regions2,504 people | 65% | 30% | 4% |
| Africa661 people | 58% | 37% | 5% |
| The Americas347 people | 65% | 31% | 4% |
| East Asia504 people | 73% | 24% | 3% |
| Europe503 people | 53% | 40% | 7% |
| South Asia489 people | 80% | 18% | 2% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- C11orf80 region
- Marker
- rs7570
- Location
- Chromosome 11 · GRCh37 66,610,645 · GRCh38 66,843,174
- Letters studied
- C and G, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- C11orf80 region · rs7570
- Location
- Chromosome 11 · GRCh37 66,610,645 · GRCh38 66,843,174
- Studied allele
- C
- Published statistic
- beta -0.0471 per C allele (SE 0.0064; the paper states no unit or standardisation), P 2.54e-13, C frequency 0.2610, locus marked 'Novel' (Supplementary Table 10, EUR meta-analysis of MVP with GPC phase 1) (Supplementary Table 10, rs7570 row)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1637 / 761 / 106 · Africa 385 / 242 / 34 · The Americas 226 / 106 / 15 · East Asia 368 / 120 / 16 · Europe 267 / 203 / 33 · South Asia 391 / 90 / 8
What it cannot tell you
This small association concerns scores on self-reported personality questionnaires. A single marker cannot assess your personality, emotional state, intelligence, capability or mental health. It gives no personality score and says nothing about any mental-health condition. Only the studied C/G allele pair is interpreted. Independent replication of this exact questionnaire association has not been verified; this card is a research finding.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology (Gupta et al., 2024)More in Mind & behaviour
- Neuroticism questionnaire association
- Extraversion questionnaire association
- Agreeableness questionnaire research association
- Conscientiousness questionnaire research association
- Subjective well-being research association
- Hand preference, CRHR1 marker
- Hand preference, MAP2 marker
- Hand preference, FURIN marker
- Clapping in time to a beat
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.