DNA Traits · Mind & behaviour
Hand preference, FURIN marker
Whether people are left-handed or right-handed.
What the research found
In the cited research, the T allele at rs6224 was associated with a lower likelihood of being left-handed in the studied cohorts.
- GG
- More often
- GT
- Middle
- TT
- Less often
- Evidence
- Genome-wide meta-analysis of three cohorts, same direction in each
- Who was studied
- Primarily European ancestry
How common each genotype is
| Region | GGMore often | GTMiddle | TTLess often |
|---|---|---|---|
| All regions2,504 people | 36% | 34% | 30% |
| Africa661 people | 2% | 23% | 75% |
| The Americas347 people | 51% | 38% | 10% |
| East Asia504 people | 71% | 26% | 3% |
| Europe503 people | 30% | 47% | 24% |
| South Asia489 people | 40% | 43% | 17% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- FURIN
- Marker
- rs6224
- Location
- Chromosome 15 · GRCh37 91,423,543 · GRCh38 90,880,313
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FURIN · rs6224
- Location
- Chromosome 15 · GRCh37 91,423,543 · GRCh38 90,880,313
- Studied allele
- T
- Published statistic
- OR 0.97 per T allele for left- versus right-handedness (23andMe OR, Table 1 footnote a); meta-analysis Z -9.39, P 6.16e-21; direction negative in 23andMe, UK Biobank and IHC; T frequency 0.47 (Table 1) (Table 1, rs6224 row: OR from the 23andMe results (footnote a); Z, P and direction from the meta-analysis)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 896 / 862 / 746 · Africa 12 / 153 / 496 · The Americas 178 / 133 / 36 · East Asia 360 / 131 / 13 · Europe 149 / 234 / 120 · South Asia 197 / 211 / 81
What it cannot tell you
Left-handedness was compared with right-handedness, and each copy shifts the odds only slightly.
Genome-wide association study identifies 48 common genetic variants associated with handedness (Cuellar-Partida et al., 2021)More in Mind & behaviour
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See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.