DNA Traits · Mind & behaviour
Hand preference, CRHR1 marker
Whether people are left-handed or right-handed.
What the research found
In the cited research, the A allele at rs55974014 was associated with a lower likelihood of being left-handed in the studied cohorts.
- CC
- More often
- AC
- Middle
- AA
- Less often
- Evidence
- Genome-wide meta-analysis of three cohorts, same direction in each
- Who was studied
- Primarily European ancestry
How common each genotype is
| Region | CCMore often | ACMiddle | AALess often |
|---|---|---|---|
| All regions2,504 people | 85% | 14% | 1% |
| Africa661 people | 97% | 3% | Not seen |
| The Americas347 people | 71% | 27% | 2% |
| East Asia504 people | >99% | <1% | Not seen |
| Europe503 people | 59% | 36% | 5% |
| South Asia489 people | 89% | 11% | <1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- CRHR1 region (17q21.31)
- Marker
- rs55974014
- Location
- Chromosome 17 · GRCh37 43,757,450 · GRCh38 45,680,084
- Letters studied
- A and C, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- CRHR1 region (17q21.31) · rs55974014
- Location
- Chromosome 17 · GRCh37 43,757,450 · GRCh38 45,680,084
- Studied allele
- A
- Published statistic
- OR 0.95 per A allele for left- versus right-handedness (the OR is taken from the 23andMe results, Table 1 footnote a); meta-analysis Z -11.43, P 2.97e-30; direction negative in 23andMe, UK Biobank and IHC; A frequency 0.21 (Table 1) (Table 1, rs55974014 row: OR from the 23andMe results (footnote a); Z, P and direction from the meta-analysis)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2122 / 346 / 36 · Africa 642 / 19 / 0 · The Americas 247 / 92 / 8 · East Asia 503 / 1 / 0 · Europe 296 / 181 / 26 · South Asia 434 / 53 / 2
What it cannot tell you
Left-handedness was compared with right-handedness. The marker tags a stretch of chromosome 17 that is common in Europe and nearly absent in East Asia.
Genome-wide association study identifies 48 common genetic variants associated with handedness (Cuellar-Partida et al., 2021)More in Mind & behaviour
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See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.