DNA Traits · Mind & behaviour
Conscientiousness questionnaire research association
A questionnaire score for how organized and careful people describe themselves.
What the research found
In the cited research, the A allele at rs936145 was associated with lower conscientiousness questionnaire scores in the studied cohorts.
- GG
- Higher score
- AG
- Middle
- AA
- Lower score
- Evidence
- Limited discovery GWAS evidence
- Who was studied
- European-ancestry multi-cohort analyses including the US Million Veteran Program; the MVP component was predominantly older men
How common each genotype is
| Region | GGHigher score | AGMiddle | AALower score |
|---|---|---|---|
| All regions2,504 people | 61% | 32% | 7% |
| Africa661 people | 81% | 17% | 2% |
| The Americas347 people | 51% | 41% | 8% |
| East Asia504 people | 76% | 23% | 2% |
| Europe503 people | 35% | 48% | 17% |
| South Asia489 people | 54% | 40% | 7% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- FOXP2 region
- Marker
- rs936145
- Location
- Chromosome 7 · GRCh37 114,297,180 · GRCh38 114,657,125
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FOXP2 region · rs936145
- Location
- Chromosome 7 · GRCh37 114,297,180 · GRCh38 114,657,125
- Studied allele
- A
- Published statistic
- beta -0.0331 per A allele (SE 0.0058; the paper states no unit or standardisation), P 1.51e-8, A frequency 0.4467, locus marked 'Novel' (Supplementary Table 9, EUR meta-analysis of MVP with GPC phase 1) (Supplementary Table 9, rs936145 row)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1531 / 805 / 168 · Africa 534 / 114 / 13 · The Americas 177 / 141 / 29 · East Asia 381 / 114 / 9 · Europe 177 / 242 / 84 · South Asia 262 / 194 / 33
What it cannot tell you
This small association concerns scores on self-reported personality questionnaires. A single marker cannot assess your personality, emotional state, intelligence, capability or mental health. It gives no personality score and says nothing about any mental-health condition. The agreeableness and conscientiousness cards use nearby FOXP2-region markers, so their results are correlated rather than independent findings. Only the studied A/G allele pair is interpreted. Independent replication of this exact questionnaire association has not been verified; this card is a research finding.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology (Gupta et al., 2024)More in Mind & behaviour
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See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.