DNA Traits · Heart & circulation
Fibrinogen level
The blood level of fibrinogen, a protein that helps blood clot.
What the research found
In the cited research, the A allele at rs1800789 was associated with higher plasma fibrinogen concentrations in the studied cohorts.
- GG
- Lower average
- AG
- Middle
- AA
- Higher average
What the study found
In the study, each copy went with fibrinogen in the blood about 0.09 g/L higher on average.
- Evidence
- Genome-wide meta-analysis across cohorts, replicated in a later study
- Who was studied
- European-ancestry adults in six population cohorts
How common each genotype is
| Region | GGLower average | AGMiddle | AAHigher average |
|---|---|---|---|
| All regions2,504 people | 71% | 25% | 3% |
| Africa661 people | 83% | 16% | <1% |
| The Americas347 people | 72% | 26% | 3% |
| East Asia504 people | 61% | 35% | 5% |
| Europe503 people | 64% | 29% | 7% |
| South Asia489 people | 74% | 24% | 2% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 25%6 of 24 copies read |
|---|---|
| First farmers6500 to 3000 BC | 12%25 of 206 copies read |
| Bronze Age3000 to 1200 BC | 17%19 of 113 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 23%52 of 225 copies read |
| Middle AgesAD 600 to 1500 | 19%45 of 231 copies read |
| Today1000 Genomes | 22%218 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
The marker
- Gene or region
- FGB
- Marker
- rs1800789
- Location
- Chromosome 4 · GRCh37 155,482,743 · GRCh38 154,561,591
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FGB · rs1800789
- Location
- Chromosome 4 · GRCh37 155,482,743 · GRCh38 154,561,591
- Studied allele
- A
- Published statistic
- beta +0.087 g/L per A (SE 0.008), P 1.75e-30, N 22,096; R2 0.2 to 2.5% by cohort; effective allele frequency 0.20 to 0.24 (Table 2). FHS means (SD) 3.2 (0.69), 3.3 (0.66), 3.4 (0.70) g/L for GG, AG, AA, n 4,489, 2,250, 283 (Table 3). Sabater-Lleal 2013: A, P 2e-127 (GWAS Catalog GCST002147) (Table 2 (Combined column) and Results)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1784 / 634 / 86 · Africa 547 / 108 / 6 · The Americas 249 / 89 / 9 · East Asia 305 / 174 / 25 · Europe 321 / 146 / 36 · South Asia 362 / 117 / 10
What it cannot tell you
Fibrinogen also rises with inflammation, smoking and age, and this marker explains less than one percent of the variation in most cohorts.
Association of novel genetic loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts (Dehghan et al., 2009)More in Heart & circulation
- LDL cholesterol concentration association
- HDL cholesterol concentration association
- Triglyceride concentration association
- Systolic blood pressure association
- Diastolic blood pressure association
- Heart conduction timing association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet count
- Platelet size
- Red blood cell size
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.