DNA Traits · Heart & circulation
LDL cholesterol, LDLR marker
The blood level of LDL cholesterol.
What the research found
In the cited research, the T allele at rs6511720 was associated with lower blood LDL cholesterol concentrations in the studied cohorts.
- GG
- Higher average
- GT
- Middle
- TT
- Lower average
What the study found
In the study, each copy went with lower LDL cholesterol on average.
- Evidence
- Genome-wide association at an established lipid locus
- Who was studied
- European-ancestry participants across multiple research cohorts
How common each genotype is
| Region | GGHigher average | GTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 83% | 16% | 1% |
| Africa661 people | 73% | 24% | 3% |
| The Americas347 people | 82% | 16% | 1% |
| East Asia504 people | 98% | 2% | Not seen |
| Europe503 people | 80% | 18% | 2% |
| South Asia489 people | 84% | 15% | <1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 1%1 of 102 copies read |
|---|---|
| First farmers6500 to 3000 BC | 11%111 of 976 copies read |
| Bronze Age3000 to 1200 BC | 12%105 of 882 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 14%214 of 1,527 copies read |
| Middle AgesAD 600 to 1500 | 10%155 of 1,483 copies read |
| Today1000 Genomes | 11%111 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- LDLR
- Marker
- rs6511720
- Location
- Chromosome 19 · GRCh37 11,202,306 · GRCh38 11,091,630
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- LDLR · rs6511720
- Location
- Chromosome 19 · GRCh37 11,202,306 · GRCh38 11,091,630
- Studied allele
- T
- Published statistic
- beta -0.26 SD per T (SE 0.04) in FHS; combined stage 1 + 2 P 2e-26, N 19,648 (Table 2; imputed, footnote c); 0.26 SD per copy (Table 2 (FHS effect size column, footnotes a and b))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2078 / 393 / 33 · Africa 485 / 158 / 18 · The Americas 286 / 57 / 4 · East Asia 492 / 12 / 0 · Europe 402 / 91 / 10 · South Asia 413 / 75 / 1
What it cannot tell you
Common LDLR markers like this one are separate from the rare LDLR mutations behind inherited very high cholesterol.
Common variants at 30 loci contribute to polygenic dyslipidemia (Kathiresan et al., 2009)More in Heart & circulation
- LDL cholesterol concentration association
- HDL cholesterol concentration association
- Triglyceride concentration association
- Systolic blood pressure association
- Diastolic blood pressure association
- Heart conduction timing association
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet count
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.