DNA Traits · Heart & circulation
Systolic blood pressure association
Blood pressure while the heart beats, the upper of the two numbers.
What the research found
In the cited research, the G allele at rs17249754 was associated with higher systolic blood pressure in the studied cohorts.
- AA
- Lower average
- AG
- Middle
- GG
- Higher average
What the study found
In the study, each copy went with systolic blood pressure about 0.93 mmHg higher on average.
- Evidence
- Genome-wide association with independent follow-up
- Who was studied
- European-ancestry discovery and independent follow-up cohorts
How common each genotype is
| Region | AALower average | AGMiddle | GGHigher average |
|---|---|---|---|
| All regions2,504 people | 6% | 30% | 64% |
| Africa661 people | 2% | 23% | 75% |
| The Americas347 people | 2% | 18% | 80% |
| East Asia504 people | 11% | 40% | 48% |
| Europe503 people | 2% | 25% | 73% |
| South Asia489 people | 12% | 44% | 43% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 88%52 of 59 copies read |
|---|---|
| First farmers6500 to 3000 BC | 91%799 of 878 copies read |
| Bronze Age3000 to 1200 BC | 86%685 of 800 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 85%881 of 1,040 copies read |
| Middle AgesAD 600 to 1500 | 82%461 of 565 copies read |
| Today1000 Genomes | 86%861 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- ATP2B1 region
- Marker
- rs17249754
- Location
- Chromosome 12 · GRCh37 90,060,586 · GRCh38 89,666,809
- Letters studied
- A and G, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- ATP2B1 region · rs17249754
- Location
- Chromosome 12 · GRCh37 90,060,586 · GRCh38 89,666,809
- Studied allele
- G
- Published statistic
- beta +0.928 mmHg SBP per coded G allele, P 1.8e-18 (combined discovery and follow-up); Table 1 (Table 1 (ATP2B1 row, CA/NCA G/A, SBP beta column); N from Supplementary Information Appendix A, Table A.2 (All data, effective sample size))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 144 / 761 / 1599 · Africa 10 / 153 / 498 · The Americas 8 / 62 / 277 · East Asia 56 / 204 / 244 · Europe 10 / 125 / 368 · South Asia 60 / 217 / 212
What it cannot tell you
The average per-allele difference in the research cohorts was less than 1 mmHg. This marker cannot tell you your current blood pressure, is not a test for high or low blood pressure, cannot calculate cardiovascular risk and does not guide treatment. Only the studied A/G allele pair is interpreted.
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (International Consortium for Blood Pressure Genome-Wide Association Studies, 2011)More in Heart & circulation
- LDL cholesterol concentration association
- HDL cholesterol concentration association
- Triglyceride concentration association
- Diastolic blood pressure association
- Heart conduction timing association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet count
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.