DNA Traits · Heart & circulation
LDL cholesterol concentration association
The blood level of LDL cholesterol.
What the research found
In the cited research, the T allele at rs12740374 was associated with lower blood LDL cholesterol concentrations in the studied cohorts.
- GG
- Higher average
- GT
- Middle
- TT
- Lower average
What the study found
In the study, each copy went with lower LDL cholesterol on average.
- Evidence
- Genome-wide association at an established lipid locus
- Who was studied
- European-ancestry participants across multiple research cohorts
How common each genotype is
| Region | GGHigher average | GTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 66% | 30% | 5% |
| Africa661 people | 55% | 41% | 4% |
| The Americas347 people | 64% | 31% | 5% |
| East Asia504 people | 92% | 8% | <1% |
| Europe503 people | 63% | 31% | 6% |
| South Asia489 people | 57% | 34% | 9% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 51%45 of 89 copies read |
|---|---|
| First farmers6500 to 3000 BC | 21%192 of 924 copies read |
| Bronze Age3000 to 1200 BC | 21%169 of 802 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 21%292 of 1,382 copies read |
| Middle AgesAD 600 to 1500 | 20%239 of 1,205 copies read |
| Today1000 Genomes | 21%214 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
The marker
- Gene or region
- SORT1 region
- Marker
- rs12740374
- Location
- Chromosome 1 · GRCh37 109,817,590 · GRCh38 109,274,968
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- SORT1 region · rs12740374
- Location
- Chromosome 1 · GRCh37 109,817,590 · GRCh38 109,274,968
- Studied allele
- T
- Published statistic
- beta -0.23 SD per T allele (SE 0.02) in FHS; combined stage 1 P 2e-42, N 19,648; Table 2; 0.23 SD per copy (Table 2 (FHS effect size column, footnotes a and b))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1641 / 747 / 116 · Africa 361 / 273 / 27 · The Americas 222 / 108 / 17 · East Asia 462 / 41 / 1 · Europe 317 / 158 / 28 · South Asia 279 / 167 / 43
What it cannot tell you
This is an association with a blood lipid measurement, not an estimate of your current lipid level. A single marker is not a test for high cholesterol, cannot predict heart attack or stroke risk and does not guide diet, medication or treatment. Only the studied G/T allele pair is interpreted.
Common variants at 30 loci contribute to polygenic dyslipidemia (Kathiresan et al., 2009)More in Heart & circulation
- HDL cholesterol concentration association
- Triglyceride concentration association
- Systolic blood pressure association
- Diastolic blood pressure association
- Heart conduction timing association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet count
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.