DNA Traits · Heart & circulation
Triglyceride concentration association
The blood level of triglycerides, the most common fat in the blood.
What the research found
In the cited research, the T allele at rs1260326 was associated with higher blood triglyceride concentrations in the studied cohorts.
- CC
- Lower average
- CT
- Middle
- TT
- Higher average
What the study found
In the study, each copy went with higher triglycerides in the blood on average.
- Evidence
- Genome-wide association at an established lipid locus
- Who was studied
- European-ancestry participants across multiple research cohorts
How common each genotype is
| Region | CCLower average | CTMiddle | TTHigher average |
|---|---|---|---|
| All regions2,504 people | 53% | 36% | 11% |
| Africa661 people | 82% | 17% | 1% |
| The Americas347 people | 43% | 41% | 16% |
| East Asia504 people | 27% | 49% | 24% |
| Europe503 people | 34% | 51% | 16% |
| South Asia489 people | 65% | 31% | 5% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 10%5 of 48 copies read |
|---|---|
| First farmers6500 to 3000 BC | 40%287 of 715 copies read |
| Bronze Age3000 to 1200 BC | 33%190 of 579 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 40%361 of 900 copies read |
| Middle AgesAD 600 to 1500 | 39%157 of 403 copies read |
| Today1000 Genomes | 41%413 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- GCKR
- Marker
- rs1260326
- Location
- Chromosome 2 · GRCh37 27,730,940 · GRCh38 27,508,073
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- GCKR · rs1260326
- Location
- Chromosome 2 · GRCh37 27,730,940 · GRCh38 27,508,073
- Studied allele
- T
- Published statistic
- beta +0.12 SD per T allele (SE 0.02) in FHS; combined stage 1 P 2e-31, N 19,840; Table 2; 0.12 SD per copy (Table 2 (FHS effect size column, footnotes a and b))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1317 / 905 / 282 · Africa 544 / 110 / 7 · The Americas 150 / 143 / 54 · East Asia 138 / 247 / 119 · Europe 169 / 255 / 79 · South Asia 316 / 150 / 23
What it cannot tell you
This is an association with a blood lipid measurement, not an estimate of your current lipid level. A single marker is not a test for high cholesterol, cannot predict heart attack or stroke risk and does not guide diet, medication or treatment. Only the studied C/T allele pair is interpreted.
Common variants at 30 loci contribute to polygenic dyslipidemia (Kathiresan et al., 2009)More in Heart & circulation
- LDL cholesterol concentration association
- HDL cholesterol concentration association
- Systolic blood pressure association
- Diastolic blood pressure association
- Heart conduction timing association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet count
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.