DNA Traits · Heart & circulation
Triglycerides, LPL marker
The blood level of triglycerides, the most common fat in the blood.
What the research found
In the cited research, the G allele at rs12678919 was associated with lower blood triglyceride concentrations in the studied cohorts.
- AA
- Higher average
- AG
- Middle
- GG
- Lower average
What the study found
In the study, each copy went with lower triglycerides in the blood on average.
- Evidence
- Genome-wide association at an established lipid locus
- Who was studied
- European-ancestry participants across multiple research cohorts
How common each genotype is
| Region | AAHigher average | AGMiddle | GGLower average |
|---|---|---|---|
| All regions2,504 people | 80% | 19% | 1% |
| Africa661 people | 78% | 21% | 1% |
| The Americas347 people | 88% | 12% | <1% |
| East Asia504 people | 77% | 22% | <1% |
| Europe503 people | 76% | 21% | 2% |
| South Asia489 people | 83% | 16% | <1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 0%0 of 45 copies read |
|---|---|
| First farmers6500 to 3000 BC | 15%85 of 574 copies read |
| Bronze Age3000 to 1200 BC | 13%63 of 477 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 13%77 of 610 copies read |
| Middle AgesAD 600 to 1500 | 11%45 of 411 copies read |
| Today1000 Genomes | 13%131 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- LPL region
- Marker
- rs12678919
- Location
- Chromosome 8 · GRCh37 19,844,222 · GRCh38 19,986,711
- Letters studied
- A and G, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- LPL region · rs12678919
- Location
- Chromosome 8 · GRCh37 19,844,222 · GRCh38 19,986,711
- Studied allele
- G
- Published statistic
- TG beta -0.25 SD per G (SE 0.03) in FHS, combined P 2e-41, N 19,840; HDL +0.23 (0.03), P 2e-34, N 19,794 (Table 2). Teslovich 2010: G -13.64 mg/dL, P 2e-115; Willer 2013: G -0.17, P 2e-199 (GWAS Catalog); 0.25 SD per copy (Table 2 (FHS effect size column))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1999 / 479 / 26 · Africa 515 / 138 / 8 · The Americas 305 / 41 / 1 · East Asia 387 / 113 / 4 · Europe 384 / 107 / 12 · South Asia 408 / 80 / 1
What it cannot tell you
Triglycerides change strongly with the last meal. The same marker also raises HDL cholesterol.
Common variants at 30 loci contribute to polygenic dyslipidemia (Kathiresan et al., 2009)More in Heart & circulation
- LDL cholesterol concentration association
- HDL cholesterol concentration association
- Triglyceride concentration association
- Systolic blood pressure association
- Diastolic blood pressure association
- Heart conduction timing association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Platelet count
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.