DNA Traits · Heart & circulation
Platelet count
The number of platelets, the cell fragments that help blood clot.
What the research found
In the cited research, the C allele at rs385893 was associated with higher platelet counts in the studied cohorts.
- TT
- Lower average
- CT
- Middle
- CC
- Higher average
What the study found
In the study, each copy went with platelets in the blood about 5.98 ×10^9/L higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European population cohorts (HaemGen consortium)
How common each genotype is
| Region | TTLower average | CTMiddle | CCHigher average |
|---|---|---|---|
| All regions2,504 people | 30% | 43% | 27% |
| Africa661 people | 57% | 37% | 6% |
| The Americas347 people | 32% | 50% | 17% |
| East Asia504 people | 5% | 34% | 61% |
| Europe503 people | 25% | 51% | 24% |
| South Asia489 people | 23% | 49% | 28% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 59%26 of 44 copies read |
|---|---|
| First farmers6500 to 3000 BC | 53%307 of 580 copies read |
| Bronze Age3000 to 1200 BC | 52%232 of 447 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 52%296 of 570 copies read |
| Middle AgesAD 600 to 1500 | 56%228 of 404 copies read |
| Today1000 Genomes | 49%496 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- AK3 region
- Marker
- rs385893
- Location
- Chromosome 9 · GRCh37 4,763,176 · GRCh38 4,763,176
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- AK3 region · rs385893
- Location
- Chromosome 9 · GRCh37 4,763,176 · GRCh38 4,763,176
- Studied allele
- C
- Published statistic
- Per C (increaser): discovery 6.951 x10^9/L (SE 1.389), P 5.6e-7; replication 5.979 (0.895), P 2.4e-11, 0.33% variance; combined 6.264 (0.753), P 8.5e-17, N 13,943 (Table 1). Kachuri 2021: P 4e-243; Verma 2024: P 2e-281 (GWAS Catalog) (Table 1 (PLT rows, replication columns))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 748 / 1087 / 669 · Africa 375 / 244 / 42 · The Americas 112 / 175 / 60 · East Asia 23 / 173 / 308 · Europe 127 / 256 / 120 · South Asia 111 / 239 / 139
What it cannot tell you
A single marker with a small effect, within the usual range of platelet counts in volunteers.
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium (Soranzo et al., 2009)More in Heart & circulation
- LDL cholesterol concentration association
- HDL cholesterol concentration association
- Triglyceride concentration association
- Systolic blood pressure association
- Diastolic blood pressure association
- Heart conduction timing association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.