DNA Traits · Heart & circulation

Platelet size

The average size of platelets, the cell fragments that help blood clot.

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Evidence · Replicated

What the research found

In the cited research, the T allele at rs2138852 was associated with larger mean platelet volume in the studied cohorts.

CC: Lower average
CT: Middle
TT: Higher average

Modest effect

Evidence: Genome-wide association with independent replication
Who was studied: European population cohorts (HaemGen consortium)

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCLower average	CTMiddle	TTHigher average
All regions2,504 people	9%	31%	60%
Africa661 people	1%	16%	83%
The Americas347 people	17%	49%	34%
East Asia504 people	Not seen	6%	94%
Europe503 people	21%	50%	29%
South Asia489 people	12%	46%	42%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	43%17 of 40 copies read
First farmers6500 to 3000 BC	51%234 of 455 copies read
Bronze Age3000 to 1200 BC	51%175 of 341 copies read
Iron Age and Antiquity1200 BC to AD 600	48%225 of 471 copies read
Middle AgesAD 600 to 1500	49%179 of 369 copies read
Today1000 Genomes	54%542 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: 2 copies
Chagyrskaya Neanderthal: 2 copies
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs2138852

The marker

Gene or region: TAOK1
Marker: rs2138852
Location: Chromosome 17 · GRCh37 27,703,349 · GRCh38 29,376,331
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: TAOK1 · rs2138852
Location: Chromosome 17 · GRCh37 27,703,349 · GRCh38 29,376,331
Studied allele: T
Published statistic: log MPV per T (increaser): discovery 0.014 (SE 0.002), P 2.5e-9; replication 0.018 (0.002), P 4.5e-15, 1.21% variance; combined 0.016 (0.002), P 1.4e-22, N 13,943 (Table 1). Meisinger 2009 (KORA, earlier MPV GWAS): C -0.02 log fL, P 7e-28 (GWAS Catalog GCST000305) (Table 1 (MPV (fl), log rows))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 233 / 780 / 1491 · Africa 9 / 105 / 547 · The Americas 58 / 170 / 119 · East Asia 0 / 31 / 473 · Europe 107 / 250 / 146 · South Asia 59 / 224 / 206

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Limits

What it cannot tell you

Platelet size was analysed on a log scale, so the card shows no plain per-copy figure.

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium (Soranzo et al., 2009)

The same topic

More in Heart & circulation

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