DNA Traits · Heart & circulation
Heart conduction timing association
The time an electrical signal takes to pass from the upper to the lower chambers of the heart.
What the research found
In the cited research, the C allele at rs6800541 was associated with a longer electrocardiogram PR interval in the studied cohorts.
- TT
- Lower average
- CT
- Middle
- CC
- Higher average
What the study found
In the study, each copy went with PR interval on the electrocardiogram about 2.52 ms higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry CHARGE cohorts and an independent European-American clinical-biobank replication
How common each genotype is
| Region | TTLower average | CTMiddle | CCHigher average |
|---|---|---|---|
| All regions2,504 people | 60% | 32% | 8% |
| Africa661 people | 90% | 9% | <1% |
| The Americas347 people | 39% | 47% | 14% |
| East Asia504 people | 70% | 27% | 3% |
| Europe503 people | 35% | 47% | 17% |
| South Asia489 people | 48% | 43% | 9% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 36%16 of 45 copies read |
|---|---|
| First farmers6500 to 3000 BC | 45%275 of 608 copies read |
| Bronze Age3000 to 1200 BC | 46%245 of 533 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 47%341 of 731 copies read |
| Middle AgesAD 600 to 1500 | 44%208 of 478 copies read |
| Today1000 Genomes | 41%414 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- SCN10A
- Marker
- rs6800541
- Location
- Chromosome 3 · GRCh37 38,774,832 · GRCh38 38,733,341
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- SCN10A · rs6800541
- Location
- Chromosome 3 · GRCh37 38,774,832 · GRCh38 38,733,341
- Studied allele
- C
- Published statistic
- beta +2.517 ms per C allele (SE 0.502; 95% CI 1.533 to 3.500), P 5.73e-7 (BioVU, Table 2); discovery (Pfeufer 2010, Table 2) +3.7687 ms per C (SE 0.2065), P 2.1e-74 (Table 2 and Results)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1495 / 806 / 203 · Africa 596 / 61 / 4 · The Americas 135 / 163 / 49 · East Asia 354 / 134 / 16 · Europe 177 / 238 / 88 · South Asia 233 / 210 / 46
What it cannot tell you
The PR interval is an ECG timing measure covering electrical activation of the atria and conduction toward the ventricles. This marker cannot tell you your current ECG interval, is not a test for a heart rhythm or conduction disorder, cannot predict cardiovascular risk and does not guide treatment. Only the studied C/T allele pair is interpreted.
Genome-wide association study of PR interval (Pfeufer et al., 2010)More in Heart & circulation
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- Systolic blood pressure association
- Diastolic blood pressure association
- LDL cholesterol, LDLR marker
- HDL cholesterol, LIPG marker
- Triglycerides, LPL marker
- Platelet count
- Platelet size
- Red blood cell size
- Fibrinogen level
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.