DNA Traits · Reproductive biology
DHT research association in older men
The blood level of DHT, a hormone the body makes from testosterone, in older men.
What the research found
In the cited research, the T allele at rs727428 was associated with lower circulating dihydrotestosterone (DHT) concentrations in the studied older men.
- CC
- Higher average
- CT
- Middle
- TT
- Lower average
- Evidence
- Discovery GWAS with within-trial subgroup consistency
- Who was studied
- European-ancestry men aged 50 to 75 in REDUCE, enrolled with elevated PSA and a negative prostate biopsy
The research behind this card was done only in men, so it is part of a report requested as male.
How common each genotype is
| Region | CCHigher average | CTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 28% | 47% | 25% |
| Africa661 people | 24% | 49% | 27% |
| The Americas347 people | 43% | 45% | 12% |
| East Asia504 people | 32% | 47% | 21% |
| Europe503 people | 35% | 45% | 20% |
| South Asia489 people | 13% | 47% | 40% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 44%27 of 62 copies read |
|---|---|
| First farmers6500 to 3000 BC | 38%368 of 959 copies read |
| Bronze Age3000 to 1200 BC | 43%387 of 898 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 41%445 of 1,093 copies read |
| Middle AgesAD 600 to 1500 | 39%223 of 566 copies read |
| Today1000 Genomes | 43%430 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- SHBG region
- Marker
- rs727428
- Location
- Chromosome 17 · GRCh37 7,537,792 · GRCh38 7,634,474
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- SHBG region · rs727428
- Location
- Chromosome 17 · GRCh37 7,537,792 · GRCh38 7,634,474
- Studied allele
- T
- Published statistic
- beta -0.103 per T allele on log-transformed serum DHT (SE 0.015), P 1.47e-11, partial R2 0.013, N 3,225 (Table 1) (Table 1, rs727428 row)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 702 / 1179 / 623 · Africa 156 / 327 / 178 · The Americas 149 / 156 / 42 · East Asia 159 / 237 / 108 · Europe 174 / 228 / 101 · South Asia 64 / 231 / 194
What it cannot tell you
This association was observed in a selected cohort of older men and explained about 1.3% of serum DHT variation in that study. Validation used two groups within the same trial, not an independent population. This card shares its SHBG-region marker with the SHBG association card, so the two are not independent genetic findings. It does not estimate your current DHT, tissue DHT or SRD5A2 enzyme activity, predict fertility or penis size, or guide hormone treatment. Only the studied C/T allele pair is interpreted. No independent replication of this exact DHT association was found.
Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men (Jin et al., 2012)More in Reproductive biology
- First period timing association
- Natural menopause timing association
- Fraternal twinning association
- Total testosterone association in men
- SHBG association
- FSH regulation association in men
- Fraternal twinning, SMAD3 marker
- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, MKL2 marker
- Voice breaking timing, JHY marker
- Voice breaking timing, 9q31 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.