DNA Traits · Reproductive biology
Natural menopause timing association
The age at which periods stop naturally.
What the research found
In the cited research, the A allele at rs16991615 was associated with later age at natural menopause in studied women.
- GG
- Earlier
- AG
- Middle
- AA
- Later
What the study found
In the study, each copy went with age at natural menopause about 0.9 years higher on average.
- Evidence
- Replicated genome-wide association with a coding variant
- Who was studied
- European-ancestry cohorts, with replication in Hispanic women
The research behind this card was done only in women, so it is part of a report requested as female.
How common each genotype is
| Region | GGEarlier | AGMiddle | AALater |
|---|---|---|---|
| All regions2,504 people | 95% | 5% | <1% |
| Africa661 people | >99% | <1% | Not seen |
| The Americas347 people | 89% | 11% | Not seen |
| East Asia504 people | All | Not seen | Not seen |
| Europe503 people | 87% | 12% | <1% |
| South Asia489 people | 95% | 4% | <1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 0%0 of 54 copies read |
|---|---|
| First farmers6500 to 3000 BC | 10%65 of 672 copies read |
| Bronze Age3000 to 1200 BC | 11%60 of 552 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 9%68 of 724 copies read |
| Middle AgesAD 600 to 1500 | 8%35 of 462 copies read |
| Today1000 Genomes | 7%67 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- MCM8
- Marker
- rs16991615
- Location
- Chromosome 20 · GRCh37 5,948,227 · GRCh38 5,967,581
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- MCM8 · rs16991615
- Location
- Chromosome 20 · GRCh37 5,948,227 · GRCh38 5,967,581
- Studied allele
- A
- Published statistic
- Replication beta +0.896 years per A allele (SE 0.096), P 7.90e-21; discovery +0.971 (SE 0.062), P 1.16e-54; combined +0.948 (SE 0.052), P 1.42e-73 (Stolk 2012 Table 1). Catalog source He 2009 Table 1: joint +1.07 years per A allele (SE 0.11), P 1.2e-21 (Table 1, rs16991615 replication row)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2376 / 123 / 5 · Africa 659 / 2 / 0 · The Americas 308 / 39 / 0 · East Asia 504 / 0 / 0 · Europe 439 / 61 / 3 · South Asia 466 / 21 / 2
What it cannot tell you
This common-variant association does not predict your menopause age, measure ovarian reserve, count remaining eggs or show how long you can conceive. It is not a test for premature ovarian insufficiency and should not guide pregnancy planning. The study concerned natural menopause rather than menopause after surgery or treatment.
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause (He et al., 2009)More in Reproductive biology
- First period timing association
- Fraternal twinning association
- Total testosterone association in men
- SHBG association
- FSH regulation association in men
- DHT research association in older men
- Fraternal twinning, SMAD3 marker
- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, MKL2 marker
- Voice breaking timing, JHY marker
- Voice breaking timing, 9q31 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.