DNA Traits · Reproductive biology
Voice breaking timing, MKL2 marker
The age at which the voice breaks during puberty, as men recall it.
What the research found
In the cited research, the C allele at rs246185 was associated with later recalled voice breaking in the studied men.
- TT
- Earlier
- CT
- Middle
- CC
- Later
What the study found
In the study, each copy went with recalled age at voice breaking about 0.09 years higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- Men of European ancestry (23andMe; replication in UK Biobank)
The research behind this card was done only in men, so it is part of a report requested as male.
How common each genotype is
| Region | TTEarlier | CTMiddle | CCLater |
|---|---|---|---|
| All regions2,504 people | 42% | 42% | 15% |
| Africa661 people | 45% | 44% | 11% |
| The Americas347 people | 61% | 33% | 6% |
| East Asia504 people | 20% | 47% | 33% |
| Europe503 people | 47% | 41% | 12% |
| South Asia489 people | 45% | 44% | 11% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 22%7 of 32 copies read |
|---|---|
| First farmers6500 to 3000 BC | 29%72 of 252 copies read |
| Bronze Age3000 to 1200 BC | 31%49 of 160 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 35%105 of 296 copies read |
| Middle AgesAD 600 to 1500 | 31%87 of 280 copies read |
| Today1000 Genomes | 33%330 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- Not read
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- Not read
The marker
- Gene or region
- MKL2 (MRTFB) region
- Marker
- rs246185
- Location
- Chromosome 16 · GRCh37 14,395,432 · GRCh38 14,301,575
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- MKL2 (MRTFB) region · rs246185
- Location
- Chromosome 16 · GRCh37 14,395,432 · GRCh38 14,301,575
- Studied allele
- C
- Published statistic
- beta +0.09 years per C allele (SE 0.01), P 5.7e-14, N 55,871 (Day 2015 Table 1, alleles C/T/0.33). UK Biobank replication at proxy rs1704528 (r2 0.88 CEU, 0.86 GBR; C with C): late vs average +0.005556 (SE 0.000839), P 5.4e-11; early -0.005105, P 4.9e-12 (Hollis 2020 Supplementary Data 1) (Table 1, rs246185 row (16p13.12, MKL2), age at voice breaking columns; N from the Table 1 column header (Age at VB, N=55,871))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1062 / 1063 / 379 · Africa 295 / 293 / 73 · The Americas 212 / 113 / 22 · East Asia 100 / 237 / 167 · Europe 235 / 206 / 62 · South Asia 220 / 214 / 55
What it cannot tell you
Studied in men of European ancestry who recalled, as adults, the age their voice broke. A single marker, one of dozens linked to puberty timing in men.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes (Day et al., 2015)More in Reproductive biology
- First period timing association
- Natural menopause timing association
- Fraternal twinning association
- Total testosterone association in men
- SHBG association
- FSH regulation association in men
- DHT research association in older men
- Fraternal twinning, SMAD3 marker
- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, JHY marker
- Voice breaking timing, 9q31 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.