DNA Traits · Reproductive biology

Natural menopause timing, TMEM150B marker

The age at which periods stop naturally.

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Evidence · Replicated

What the research found

In the cited research, the G allele at rs11668344 was associated with earlier age at natural menopause in studied women.

AA: Later
AG: Middle
GG: Earlier

Slight effect

What the study found

In the study, each copy went with age at natural menopause about 0.42 years lower on average.

Women of European descent with natural menopause between 40 and 60, in 21 replication studies · Table 1, rs11668344 row (region 19a), Replication line

Evidence: Genome-wide association with independent replication
Who was studied: Women of European descent

The research behind this card was done only in women, so it is part of a report requested as female.

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	AALater	AGMiddle	GGEarlier
All regions2,504 people	46%	42%	12%
Africa661 people	39%	48%	13%
The Americas347 people	36%	48%	15%
East Asia504 people	80%	19%	<1%
Europe503 people	43%	47%	11%
South Asia489 people	31%	46%	23%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	15%8 of 55 copies read
First farmers6500 to 3000 BC	33%292 of 873 copies read
Bronze Age3000 to 1200 BC	38%307 of 812 copies read
Iron Age and Antiquity1200 BC to AD 600	34%352 of 1,029 copies read
Middle AgesAD 600 to 1500	34%148 of 431 copies read
Today1000 Genomes	34%344 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: No copies
Vindija Neanderthal: No copies
Chagyrskaya Neanderthal: No copies
Denisovan: No copies

Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs11668344

The marker

Gene or region: TMEM150B / BRSK1 region
Marker: rs11668344
Location: Chromosome 19 · GRCh37 55,833,664 · GRCh38 55,322,296
Letters studied: A and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: TMEM150B / BRSK1 region · rs11668344
Location: Chromosome 19 · GRCh37 55,833,664 · GRCh38 55,322,296
Studied allele: G
Published statistic: Replication beta -0.415 years per G allele (SE 0.048), P 2.65e-18, G frequency 0.36; discovery -0.416 (SE 0.03), P 5.94e-43, 38,968 women; combined -0.416 (SE 0.026), P 1.45e-59 (Stolk 2012 Table 1). Day 2015 Table 1: -0.41 (SE 0.02) per G, P 5.5e-85, 69,329 women (Table 1, rs11668344 row (region 19a), Replication line)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1149 / 1046 / 309 · Africa 256 / 320 / 85 · The Americas 126 / 168 / 53 · East Asia 403 / 97 / 4 · Europe 214 / 234 / 55 · South Asia 150 / 227 / 112

See this card in the sample report

Limits

What it cannot tell you

Studied in women of European descent and concerns natural menopause, not menopause after surgery or treatment. A single marker, one of about 290 linked to the age at natural menopause.

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways (Stolk et al., 2012)

The same topic

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