DNA Traits · Reproductive biology
FSH regulation association in men
The blood level of FSH, a hormone that acts on the testes, in men.
What the research found
In the cited research, the T allele at rs10835638 was associated with lower follicle-stimulating hormone (FSH) concentrations in the studied male cohorts.
- GG
- Higher average
- GT
- Middle
- TT
- Lower average
What the study found
In the study, the average FSH in blood, by genotype:
- GGNo copy
- 3.2 IU/L
- GTOne copy
- 2.7 IU/L
- TTTwo copies
- 2.4 IU/L
- Evidence
- Replicated candidate-variant association with promoter-function evidence
- Who was studied
- Young men from Estonia, Latvia and Lithuania; earlier Estonian male cohorts
The research behind this card was done only in men, so it is part of a report requested as male.
How common each genotype is
| Region | GGHigher average | GTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 84% | 15% | <1% |
| Africa661 people | 91% | 9% | <1% |
| The Americas347 people | 79% | 19% | 2% |
| East Asia504 people | 94% | 6% | Not seen |
| Europe503 people | 73% | 25% | 2% |
| South Asia489 people | 80% | 19% | 1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 33%16 of 48 copies read |
|---|---|
| First farmers6500 to 3000 BC | 18%62 of 348 copies read |
| Bronze Age3000 to 1200 BC | 13%37 of 275 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 13%85 of 672 copies read |
| Middle AgesAD 600 to 1500 | 16%133 of 842 copies read |
| Today1000 Genomes | 14%144 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- Not read
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- FSHB promoter
- Marker
- rs10835638
- Location
- Chromosome 11 · GRCh37 30,252,352 · GRCh38 30,230,805
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FSHB promoter · rs10835638
- Location
- Chromosome 11 · GRCh37 30,252,352 · GRCh38 30,230,805
- Studied allele
- T
- Published statistic
- T-allele effect -0.41 IU/liter per allele, additive model P 1.11e-6, N 1,054 (Abstract; Table 2). 2022 validation in infertile men: beta -0.29 (SE 0.06) on Box-Cox FSH, P 5.55e-7; mean FSH GG 5.8, GT 4.6, TT 3.6 IU/l (n 803 / 294 / 26) (Schubert 2022, Table 3) (Table 2, FSH (IU/liter) mean (sd) row; Results)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2107 / 374 / 23 · Africa 601 / 58 / 2 · The Americas 273 / 67 / 7 · East Asia 472 / 32 / 0 · Europe 368 / 126 / 9 · South Asia 393 / 91 / 5
What it cannot tell you
The association shown here concerns FSH in men. In the cited population cohort, sperm motility and morphology were not associated with this marker, and sperm-count differences were not statistically significant. It does not measure your current FSH or sperm quality, cannot tell whether you can conceive, is not a test for infertility and should not guide fertility treatment. Only the studied G/T allele pair is interpreted.
Genetically Determined Dosage of Follicle-Stimulating Hormone (FSH) Affects Male Reproductive Parameters (Grigorova et al., 2011)More in Reproductive biology
- First period timing association
- Natural menopause timing association
- Fraternal twinning association
- Total testosterone association in men
- SHBG association
- DHT research association in older men
- Fraternal twinning, SMAD3 marker
- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, MKL2 marker
- Voice breaking timing, JHY marker
- Voice breaking timing, 9q31 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.