DNA Traits · Reproductive biology
Voice breaking timing, 9q31 marker
The age at which the voice breaks during puberty, as men recall it.
What the research found
In the cited research, the G allele at rs9408817 was associated with later recalled voice breaking in the studied men.
- AA
- Earlier
- AG
- Middle
- GG
- Later
What the study found
In the study, each copy went with recalled age at voice breaking about 0.07 years higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- Men of European ancestry (23andMe; replication in UK Biobank)
The research behind this card was done only in men, so it is part of a report requested as male.
How common each genotype is
| Region | AAEarlier | AGMiddle | GGLater |
|---|---|---|---|
| All regions2,504 people | 10% | 42% | 48% |
| Africa661 people | 10% | 44% | 46% |
| The Americas347 people | 10% | 49% | 41% |
| East Asia504 people | 18% | 47% | 35% |
| Europe503 people | 11% | 43% | 46% |
| South Asia489 people | 2% | 28% | 70% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- 9q31.2 region (near TMEM38B)
- Marker
- rs9408817
- Location
- Chromosome 9 · GRCh37 108,911,979 · GRCh38 106,149,698
- Letters studied
- A and G, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- 9q31.2 region (near TMEM38B) · rs9408817
- Location
- Chromosome 9 · GRCh37 108,911,979 · GRCh38 106,149,698
- Studied allele
- G
- Published statistic
- beta +0.07 years per G allele (SE 0.01), P 1.6e-10, N 55,871 (Day 2015 Table 1, alleles G/A/0.67). Same marker in UK Biobank men (Hollis 2020 Supplementary Data 2): late vs average +0.006704 (SE 0.000859), P 6.4e-15; early -0.004805, P 1.5e-10; multi-trait estimate +0.041 years, P 1.3e-32 (Table 1, rs9408817 row (9q31.2, TMEM38B), age at voice breaking columns; N from the Table 1 column header (Age at VB, N=55,871))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 255 / 1049 / 1200 · Africa 66 / 288 / 307 · The Americas 35 / 169 / 143 · East Asia 89 / 237 / 178 · Europe 53 / 218 / 232 · South Asia 12 / 137 / 340
What it cannot tell you
Studied in men of European ancestry who recalled, as adults, the age their voice broke. A single marker, one of dozens linked to puberty timing in men.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes (Day et al., 2015)More in Reproductive biology
- First period timing association
- Natural menopause timing association
- Fraternal twinning association
- Total testosterone association in men
- SHBG association
- FSH regulation association in men
- DHT research association in older men
- Fraternal twinning, SMAD3 marker
- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, MKL2 marker
- Voice breaking timing, JHY marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.