DNA Traits · Reproductive biology
Fraternal twinning association
The chance of conceiving non-identical twins without fertility treatment.
What the research found
In the cited research, the G allele at rs11031006 was associated with a higher likelihood of a spontaneous fraternal-twin birth in women studied.
- AA
- Less likely
- AG
- Middle
- GG
- More likely
What the study found
In the study, each copy went with chance of a twin birth, in relative terms about 18% higher on average.
- Evidence
- Replicated genome-wide association
- Who was studied
- European-ancestry mothers, with replication in Icelandic birth records
The research behind this card was done only in women, so it is part of a report requested as female.
How common each genotype is
| Region | AALess likely | AGMiddle | GGMore likely |
|---|---|---|---|
| All regions2,504 people | <1% | 14% | 85% |
| Africa661 people | <1% | 9% | 91% |
| The Americas347 people | 2% | 15% | 83% |
| East Asia504 people | Not seen | 6% | 94% |
| Europe503 people | 2% | 24% | 74% |
| South Asia489 people | 1% | 18% | 81% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 75%27 of 36 copies read |
|---|---|
| First farmers6500 to 3000 BC | 90%325 of 361 copies read |
| Bronze Age3000 to 1200 BC | 89%243 of 274 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 88%372 of 424 copies read |
| Middle AgesAD 600 to 1500 | 88%328 of 372 copies read |
| Today1000 Genomes | 86%864 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- FSHB region
- Marker
- rs11031006
- Location
- Chromosome 11 · GRCh37 30,226,528 · GRCh38 30,204,981
- Letters studied
- A and G, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- FSHB region · rs11031006
- Location
- Chromosome 11 · GRCh37 30,226,528 · GRCh38 30,204,981
- Studied allele
- G
- Published statistic
- Discovery OR 1.41 per G allele (95% CI 1.29 to 1.53), P 1.54e-9, 1,980 mothers of spontaneous DZ twins and 12,953 controls; Iceland replication OR 1.14 (95% CI 1.06 to 1.22), P 3e-3, 3,597 mothers of twins and 297,348 controls; combined P 1.25e-10 (Table 3). Twin-birth risk +18% per maternal G allele, about 90,000 Icelandic births (Results) (Abstract; Results paragraph on twin births in Iceland)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 24 / 351 / 2129 · Africa 1 / 60 / 600 · The Americas 7 / 53 / 287 · East Asia 0 / 32 / 472 · Europe 11 / 120 / 372 · South Asia 5 / 86 / 398
What it cannot tell you
This maternal association concerns spontaneous fraternal twins, not identical twins or twins conceived after fertility treatment. It does not estimate your absolute chance of twins, predict a pregnancy or measure fertility. A person who does not ovulate cannot apply this association to a partner’s chance of twins.
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility (Mbarek et al., 2016)More in Reproductive biology
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- DHT research association in older men
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- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, MKL2 marker
- Voice breaking timing, JHY marker
- Voice breaking timing, 9q31 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.