Evidence · Replicated

What the research found

In the cited research, the T allele at rs365132 was associated with later age at natural menopause in studied women.

GG: Earlier
GT: Middle
TT: Later

Slight effect

What the study found

In the study, each copy went with age at natural menopause about 0.32 years higher on average.

Women of European descent with natural menopause between 40 and 60, in 21 replication studies · Table 1, rs365132 row (region 5b), Replication line

Evidence: Genome-wide association with independent replication
Who was studied: Women of European descent

The research behind this card was done only in women, so it is part of a report requested as female.

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	GGEarlier	GTMiddle	TTLater
All regions2,504 people	20%	42%	38%
Africa661 people	1%	21%	78%
The Americas347 people	33%	46%	21%
East Asia504 people	25%	51%	23%
Europe503 people	26%	50%	24%
South Asia489 people	26%	49%	26%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	52%31 of 60 copies read
First farmers6500 to 3000 BC	50%227 of 454 copies read
Bronze Age3000 to 1200 BC	47%162 of 347 copies read
Iron Age and Antiquity1200 BC to AD 600	45%357 of 785 copies read
Middle AgesAD 600 to 1500	49%469 of 959 copies read
Today1000 Genomes	49%491 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: Not read
Chagyrskaya Neanderthal: Not read
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs365132

The marker

Gene or region: UIMC1 (RAP80)
Marker: rs365132
Location: Chromosome 5 · GRCh37 176,378,574 · GRCh38 176,951,573
Letters studied: G and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: UIMC1 (RAP80) · rs365132
Location: Chromosome 5 · GRCh37 176,378,574 · GRCh38 176,951,573
Studied allele: T
Published statistic: Replication beta +0.319 years per T allele (SE 0.046), P 4.26e-12, T frequency 0.494; discovery +0.275 (SE 0.029), P 1.90e-21; combined +0.287 (SE 0.025), P 9.11e-32 (Stolk 2012 Table 1). He 2009 Table 1 joint +0.39 (SE 0.052) per T, P 8.4e-14; Day 2015 Table 1 -0.24 (SE 0.02) per G, P 1.4e-33 (Table 1, rs365132 row (region 5b), Replication line)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 508 / 1045 / 951 · Africa 9 / 137 / 515 · The Americas 115 / 158 / 74 · East Asia 127 / 259 / 118 · Europe 131 / 253 / 119 · South Asia 126 / 238 / 125

See this card in the sample report

Limits

What it cannot tell you

Studied in women of European descent and concerns natural menopause, not menopause after surgery or treatment. A single marker, one of about 290 linked to the age at natural menopause.

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways (Stolk et al., 2012)

The same topic

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