DNA Traits · Reproductive biology
Total testosterone association in men
The total amount of testosterone in the blood, in men.
What the research found
In the cited research, the T allele at rs12150660 was associated with higher total testosterone concentrations in the studied male cohorts.
- GG
- Lower average
- GT
- Middle
- TT
- Higher average
What the study found
In the study, each copy went with total testosterone in blood about 31.8 ng/dL higher on average.
- Evidence
- Genome-wide association with independent replication cohorts
- Who was studied
- European-ancestry men aged 18 to 98 in ten cohorts
The research behind this card was done only in men, so it is part of a report requested as male.
How common each genotype is
| Region | GGLower average | GTMiddle | TTHigher average |
|---|---|---|---|
| All regions2,504 people | 83% | 15% | 2% |
| Africa661 people | 93% | 7% | <1% |
| The Americas347 people | 74% | 24% | 2% |
| East Asia504 people | >99% | <1% | Not seen |
| Europe503 people | 57% | 37% | 6% |
| South Asia489 people | 87% | 12% | 1% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 17%15 of 89 copies read |
|---|---|
| First farmers6500 to 3000 BC | 21%214 of 1,002 copies read |
| Bronze Age3000 to 1200 BC | 17%152 of 913 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 22%341 of 1,552 copies read |
| Middle AgesAD 600 to 1500 | 19%252 of 1,331 copies read |
| Today1000 Genomes | 24%243 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- Not read
- Chagyrskaya Neanderthal
- Not read
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- SHBG region
- Marker
- rs12150660
- Location
- Chromosome 17 · GRCh37 7,521,915 · GRCh38 7,618,597
- Letters studied
- G and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- SHBG region · rs12150660
- Location
- Chromosome 17 · GRCh37 7,521,915 · GRCh38 7,618,597
- Studied allele
- T
- Published statistic
- beta +31.8 ng/dl per T allele (SE 2.3), P 1.2e-41, combined N 14,367; discovery +26.4 (SE 3.1), P 1.9e-17, N 8,938; replication +38.8 (SE 3.6), P 2.3e-27, N 5,429 (Table 1). Calculated free testosterone: combined 0.0, P 0.39 (Table 1) (Table 1, testosterone (ng/dl), combined columns)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 2087 / 371 / 46 · Africa 612 / 45 / 4 · The Americas 257 / 82 / 8 · East Asia 503 / 1 / 0 · Europe 289 / 185 / 29 · South Asia 426 / 58 / 5
What it cannot tell you
This association was established in men and concerns total testosterone, not free testosterone. The marker also associates with SHBG, the hormone-binding protein; it did not significantly associate with calculated free testosterone in this study. It does not estimate a current hormone concentration, is not a test for low testosterone, does not predict fertility or penis size, and should not guide hormone treatment.
Genetic determinants of serum testosterone concentrations in men (Ohlsson et al., 2011)More in Reproductive biology
- First period timing association
- Natural menopause timing association
- Fraternal twinning association
- SHBG association
- FSH regulation association in men
- DHT research association in older men
- Fraternal twinning, SMAD3 marker
- Natural menopause timing, TDRD3 marker
- Natural menopause timing, TMEM150B marker
- Natural menopause timing, UIMC1 marker
- Natural menopause timing, ASH2L marker
- First period timing, 9q31 marker
- First period timing, MKL2 marker
- Voice breaking timing, LIN28B marker
- Voice breaking timing, MKL2 marker
- Voice breaking timing, JHY marker
- Voice breaking timing, 9q31 marker
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.