DNA Traits · Body & performance
Adult height association
How tall a person is as an adult.
What the research found
In the cited research, the C allele at rs1042725 was associated with greater adult height in the studied cohorts.
- TT
- Lower average
- CT
- Middle
- CC
- Higher average
What the study found
In the study, each copy went with adult height about 0.4 cm higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry discovery and replication cohorts
How common each genotype is
| Region | TTLower average | CTMiddle | CCHigher average |
|---|---|---|---|
| All regions2,504 people | 37% | 42% | 21% |
| Africa661 people | 12% | 44% | 45% |
| The Americas347 people | 42% | 45% | 13% |
| East Asia504 people | 68% | 29% | 3% |
| Europe503 people | 30% | 48% | 22% |
| South Asia489 people | 46% | 43% | 11% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 69%33 of 48 copies read |
|---|---|
| First farmers6500 to 3000 BC | 43%279 of 647 copies read |
| Bronze Age3000 to 1200 BC | 49%296 of 608 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 49%398 of 812 copies read |
| Middle AgesAD 600 to 1500 | 44%228 of 513 copies read |
| Today1000 Genomes | 46%466 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
The marker
- Gene or region
- HMGA2
- Marker
- rs1042725
- Location
- Chromosome 12 · GRCh37 66,358,347 · GRCh38 65,964,567
- Letters studied
- C and T, with C as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- HMGA2 · rs1042725
- Location
- Chromosome 12 · GRCh37 66,358,347 · GRCh38 65,964,567
- Studied allele
- C
- Published statistic
- 0.07 adult height Z-score units per C allele (95% CI 0.05 to 0.09), P 3e-11 in replication (Table 1: 0.067, SE 0.010); all studies 0.074 (SE 0.009), P 4e-16 (Abstract (19,064 adults from four further studies; about 0.4 cm per C allele); Results paragraph on the adult replication studies (0.07 Z-score units, about 0.4 cm); Table 1 (combined replication 0.067, SE 0.010))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 937 / 1043 / 524 · Africa 77 / 289 / 295 · The Americas 145 / 157 / 45 · East Asia 341 / 148 / 15 · Europe 150 / 240 / 113 · South Asia 224 / 209 / 56
What it cannot tell you
The adult replication effect was about 0.4 cm per C allele on average. Height involves many genes and developmental factors. This marker cannot predict your height, a child's final height or response to growth treatment, and it is not a test for a growth disorder.
A common variant of HMGA2 is associated with adult and childhood height in the general population (Weedon et al., 2007)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Handgrip strength (TGFA)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.