DNA Traits · Body & performance
Handgrip strength (TGFA)
How hard the hand can squeeze, a common measure of muscle strength.
What the research found
In the cited research, the A allele at rs958685 was associated with higher maximal handgrip strength in the studied cohorts.
- CC
- Lower average
- AC
- Middle
- AA
- Higher average
What the study found
In the study, each copy went with maximal handgrip strength about 0.16 kg higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry adults (UK Biobank and eight stage-two cohorts)
How common each genotype is
| Region | CCLower average | ACMiddle | AAHigher average |
|---|---|---|---|
| All regions2,504 people | 21% | 48% | 31% |
| Africa661 people | 21% | 47% | 32% |
| The Americas347 people | 17% | 48% | 35% |
| East Asia504 people | 17% | 46% | 37% |
| Europe503 people | 24% | 50% | 25% |
| South Asia489 people | 24% | 48% | 28% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- TGFA
- Marker
- rs958685
- Location
- Chromosome 2 · GRCh37 70,703,847 · GRCh38 70,476,715
- Letters studied
- A and C, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- TGFA · rs958685
- Location
- Chromosome 2 · GRCh37 70,703,847 · GRCh38 70,476,715
- Studied allele
- A
- Published statistic
- Combined 0.157 kg per A (SE 0.022), P 4.8e-13, N 191,754; stage one 0.154 (SE 0.026), P 2.8e-9, N 142,035; stage two 0.164 (SE 0.040), P 3.8e-5, N 49,719 (Table 1; Supplementary Table 2A); stage-two heterogeneity P 0.93 (Supplementary Table 2B) (Table 1 (combined columns))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 518 / 1199 / 787 · Africa 137 / 313 / 211 · The Americas 59 / 165 / 123 · East Asia 84 / 233 / 187 · Europe 121 / 254 / 128 · South Asia 117 / 234 / 138
What it cannot tell you
Handgrip is one measured form of strength, and each copy went with a small fraction of a kilogram on average.
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness (Willems et al., 2017)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Adult height association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.