DNA Traits · Body & performance
Waist-to-hip ratio in women (ADAMTS9)
Waist size compared with hip size, which reflects where the body stores fat, in women.
What the research found
In the cited research, the G allele at rs2371767 was associated with a higher waist-to-hip ratio after adjustment for BMI in the studied women.
- CC
- Lower average
- CG
- Middle
- GG
- Higher average
What the study found
In the study, each copy went with higher waist-to-hip ratio adjusted for BMI on average.
- Evidence
- Genome-wide association meta-analysis across many cohorts, strongest in women
- Who was studied
- European-ancestry women
The research behind this card was done only in women, so it is part of a report requested as female.
How common each genotype is
| Region | CCLower average | CGMiddle | GGHigher average |
|---|---|---|---|
| All regions2,504 people | 21% | 40% | 39% |
| Africa661 people | 43% | 44% | 13% |
| The Americas347 people | 7% | 37% | 56% |
| East Asia504 people | 5% | 35% | 61% |
| Europe503 people | 9% | 36% | 56% |
| South Asia489 people | 28% | 47% | 25% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 93%111 of 119 copies read |
|---|---|
| First farmers6500 to 3000 BC | 69%812 of 1,170 copies read |
| Bronze Age3000 to 1200 BC | 71%815 of 1,150 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 68%1,207 of 1,777 copies read |
| Middle AgesAD 600 to 1500 | 69%1,138 of 1,648 copies read |
| Today1000 Genomes | 74%740 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
The marker
- Gene or region
- ADAMTS9
- Marker
- rs2371767
- Location
- Chromosome 3 · GRCh37 64,718,258 · GRCh38 64,732,582
- Letters studied
- C and G, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- ADAMTS9 · rs2371767
- Location
- Chromosome 3 · GRCh37 64,718,258 · GRCh38 64,732,582
- Studied allele
- G
- Published statistic
- Women 0.056 (P 1.2e-26, N 108,624); men 0.012 (P 0.035, N 86,016); sex difference P 3.6e-9; sex-combined 0.036 (P 1.6e-20, N 194,506); G frequency 0.72 (Shungin 2015 Table 1). UK Biobank, sex-combined: G +0.04, P 6e-92 (Lotta 2018, GWAS Catalog); 0.06 SD per copy (Table 1)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 514 / 1002 / 988 · Africa 284 / 290 / 87 · The Americas 26 / 128 / 193 · East Asia 23 / 174 / 307 · Europe 43 / 180 / 280 · South Asia 138 / 230 / 121
What it cannot tell you
Studied in women; in men the association was much weaker. The outcome was waist-to-hip ratio adjusted for BMI.
New genetic loci link adipose and insulin biology to body fat distribution (Shungin et al., 2015)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Adult height association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Handgrip strength (TGFA)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.