Evidence · Replicated

What the research found

In the cited research, the C allele at rs2943650 was associated with higher body fat percentage in the studied cohorts.

TT: Lower average
CT: Middle
CC: Higher average

Slight effect

What the study found

In the study, each copy went with body fat percentage about 0.34 percentage points higher on average.

US Hispanic/Latino adults (Hispanic Community Health Study/Study of Latinos) · Table 2

Evidence: Replicated association at a genome-wide significant locus
Who was studied: European-ancestry discovery with independent US Hispanic/Latino replication

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	TTLower average	CTMiddle	CCHigher average
All regions2,504 people	48%	35%	17%
Africa661 people	14%	44%	43%
The Americas347 people	58%	35%	7%
East Asia504 people	87%	13%	<1%
Europe503 people	40%	46%	15%
South Asia489 people	57%	36%	7%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	51%25 of 49 copies read
First farmers6500 to 3000 BC	53%410 of 774 copies read
Bronze Age3000 to 1200 BC	40%267 of 668 copies read
Iron Age and Antiquity1200 BC to AD 600	42%379 of 902 copies read
Middle AgesAD 600 to 1500	39%190 of 484 copies read
Today1000 Genomes	37%376 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: Not read
Chagyrskaya Neanderthal: Not read
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs2943650

The marker

Gene or region: IRS1 region
Marker: rs2943650
Location: Chromosome 2 · GRCh37 227,105,921 · GRCh38 226,241,205
Letters studied: C and T, with C as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: IRS1 region · rs2943650
Location: Chromosome 2 · GRCh37 227,105,921 · GRCh38 226,241,205
Studied allele: C
Published statistic: beta 0.34 (SE 0.11) percentage points of body fat per C allele, P 0.002; women 0.41 (SE 0.14), P 0.003; men 0.28 (SE 0.18), P 0.11; sex difference P 0.57; Table 2 (Table 2)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 1207 / 880 / 417 · Africa 90 / 290 / 281 · The Americas 201 / 120 / 26 · East Asia 438 / 64 / 2 · Europe 200 / 230 / 73 · South Asia 278 / 176 / 35

See this card in the sample report

Limits

What it cannot tell you

Effects differed in size across sex and ancestry groups. Body fat amount and metabolic health are separate outcomes: this marker cannot tell you your body fat percentage, visceral fat or metabolic risk, and it does not choose a weight-loss plan. Only the studied C/T allele pair is interpreted.

Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in US Hispanics/Latinos (Qi et al., 2016)

The same topic

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