DNA Traits · Body & performance
Bone mineral density (CYP24A1)
How dense the bone at the hip is, measured with a DXA scan.
What the research found
In the cited research, the T allele at rs35194449 was associated with lower total-hip bone mineral density in the studied cohort.
- CC
- Higher average
- CT
- Middle
- TT
- Lower average
What the study found
In the study, each copy went with lower total-hip bone mineral density measured by DXA on average.
- Evidence
- Genome-wide association in UK Biobank DXA scans, not yet independently replicated
- Who was studied
- UK Biobank adults of European ancestry with DXA scans
How common each genotype is
| Region | CCHigher average | CTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 61% | 32% | 7% |
| Africa661 people | 76% | 23% | 2% |
| The Americas347 people | 40% | 47% | 13% |
| East Asia504 people | 73% | 25% | 3% |
| Europe503 people | 60% | 31% | 9% |
| South Asia489 people | 45% | 44% | 11% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- CYP24A1 / BCAS1 region
- Marker
- rs35194449
- Location
- Chromosome 20 · GRCh37 52,742,047 · GRCh38 54,125,508
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- CYP24A1 / BCAS1 region · rs35194449
- Location
- Chromosome 20 · GRCh37 52,742,047 · GRCh38 54,125,508
- Studied allele
- T
- Published statistic
- Total-hip BMD -0.065 SD per T (SE 0.0103), P 3.1e-10, N 29,480, T frequency 0.1964 (Table S2); men -0.069 (SE 0.014), P 1.35e-6, N 15,632; women -0.061 (SE 0.015), P 5.2e-5, N 13,848 (Table S8). Perfect proxy rs6013897 (r2 1.0 CEU/GBR): femoral neck +0.068 SD per T allele of that SNP (= -0.0678 per its A), P 4.56e-11, N 29,585 (Table 1 and Table S2); 0.07 SD per copy (Supplementary Table S2; Supplementary Table S8 (by sex))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1532 / 807 / 165 · Africa 501 / 149 / 11 · The Americas 140 / 162 / 45 · East Asia 367 / 124 / 13 · Europe 304 / 155 / 44 · South Asia 220 / 217 / 52
What it cannot tell you
Found in about 30,000 UK Biobank scans and not yet confirmed in an independent cohort.
Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance (Qian et al., 2025)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Adult height association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Handgrip strength (TGFA)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.