DNA Traits · Body & performance
Waist-to-hip ratio in women (GRB14)
Waist size compared with hip size, which reflects where the body stores fat, in women.
What the research found
In the cited research, the T allele at rs10195252 was associated with a higher waist-to-hip ratio after adjustment for BMI in the studied women.
- CC
- Lower average
- CT
- Middle
- TT
- Higher average
What the study found
In the study, each copy went with higher waist-to-hip ratio adjusted for BMI on average.
- Evidence
- Genome-wide association with independent replication, in women only
- Who was studied
- European-ancestry women
The research behind this card was done only in women, so it is part of a report requested as female.
How common each genotype is
| Region | CCLower average | CTMiddle | TTHigher average |
|---|---|---|---|
| All regions2,504 people | 23% | 33% | 44% |
| Africa661 people | 64% | 32% | 4% |
| The Americas347 people | 9% | 35% | 57% |
| East Asia504 people | 1% | 17% | 82% |
| Europe503 people | 19% | 50% | 31% |
| South Asia489 people | 5% | 33% | 62% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 70%35 of 50 copies read |
|---|---|
| First farmers6500 to 3000 BC | 59%416 of 711 copies read |
| Bronze Age3000 to 1200 BC | 62%390 of 627 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 67%608 of 910 copies read |
| Middle AgesAD 600 to 1500 | 72%385 of 532 copies read |
| Today1000 Genomes | 56%561 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- GRB14 / COBLL1 region
- Marker
- rs10195252
- Location
- Chromosome 2 · GRCh37 165,513,091 · GRCh38 164,656,581
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- GRB14 / COBLL1 region · rs10195252
- Location
- Chromosome 2 · GRCh37 165,513,091 · GRCh38 164,656,581
- Studied allele
- T
- Published statistic
- Women: discovery 0.053 (P 6.33e-15), follow-up 0.054 (P 4.95e-21), combined 0.054 (P 3.84e-34); men combined 0.010 (P 0.043); sex difference P 1.41e-11 (Heid 2010 Table 2). Shungin 2015 Table 1: women 0.052 (P 4.7e-30, N 116,329), men -0.003 (P 0.53), sex difference P 2.4e-17; 0.05 SD per copy (Table 2 (women, combined column))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 580 / 828 / 1096 · Africa 421 / 214 / 26 · The Americas 30 / 120 / 197 · East Asia 6 / 85 / 413 · Europe 98 / 249 / 156 · South Asia 25 / 160 / 304
What it cannot tell you
Studied in women; in men the association was close to zero. The outcome was waist-to-hip ratio adjusted for BMI.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (Heid et al., 2010)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Adult height association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Handgrip strength (TGFA)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.