DNA Traits · Body & performance
Lean body mass (ADAMTSL3)
The weight of everything in the body that is not fat, such as muscle and bone.
What the research found
In the cited research, the T allele at rs4842924 was associated with lower whole-body lean mass after adjustment for fat mass and height in the studied cohorts.
- CC
- Higher average
- CT
- Middle
- TT
- Lower average
What the study found
In the study, each copy went with whole-body lean mass after adjustment for height and fat mass about 0.12 kg lower on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry adults
How common each genotype is
| Region | CCHigher average | CTMiddle | TTLower average |
|---|---|---|---|
| All regions2,504 people | 11% | 40% | 49% |
| Africa661 people | 3% | 28% | 69% |
| The Americas347 people | 10% | 36% | 54% |
| East Asia504 people | 7% | 41% | 51% |
| Europe503 people | 21% | 52% | 28% |
| South Asia489 people | 19% | 46% | 35% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- ADAMTSL3
- Marker
- rs4842924
- Location
- Chromosome 15 · GRCh37 84,587,607 · GRCh38 83,918,855
- Letters studied
- C and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- ADAMTSL3 · rs4842924
- Location
- Chromosome 15 · GRCh37 84,587,607 · GRCh38 83,918,855
- Studied allele
- T
- Published statistic
- beta -0.12 kg per T (SE 0.02), P 1.4e-8, N 85,519 (combined EU); discovery -0.17 (SE 0.03), P 1.4e-7, N 38,292; replication -0.08 (SE 0.03), P 3.9e-3, N 47,227; appendicular lean mass combined -0.06 (SE 0.01), P 5.0e-8 (Table 1) (Table 1 (Combined EU columns))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 284 / 1004 / 1216 · Africa 19 / 186 / 456 · The Americas 33 / 125 / 189 · East Asia 37 / 208 / 259 · Europe 104 / 260 / 139 · South Asia 91 / 225 / 173
What it cannot tell you
Lean mass includes organs and bone as well as muscle, and the study adjusted for height and fat mass.
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (Zillikens et al., 2017)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Adult height association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Handgrip strength (TGFA)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.