Evidence · Replicated

What the research found

In the cited research, the T allele at rs7692995 was associated with greater adult height in the studied cohorts.

CC: Lower average
CT: Middle
TT: Higher average

Slight effect

What the study found

In the study, each copy went with higher adult height on average.

European-ancestry adults in 79 GWAS (GIANT) · 253,241 people · Supplementary Table 1

Evidence: Genome-wide association, replicated through a perfect proxy and in a later Hispanic/Latino GWAS
Who was studied: European-ancestry adults

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	CCLower average	CTMiddle	TTHigher average
All regions2,504 people	9%	33%	58%
Africa661 people	21%	47%	32%
The Americas347 people	5%	24%	71%
East Asia504 people	4%	25%	72%
Europe503 people	1%	22%	76%
South Asia489 people	9%	40%	50%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

rs7692995

The marker

Gene or region: LCORL
Marker: rs7692995
Location: Chromosome 4 · GRCh37 17,936,634 · GRCh38 17,935,011
Letters studied: C and T, with T as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: LCORL · rs7692995
Location: Chromosome 4 · GRCh37 17,936,634 · GRCh38 17,935,011
Studied allele: T
Published statistic: GWAS meta-analysis: T +0.0743 SD (SE 0.0041), P 1.06e-71, N 253,241, T frequency 0.848 (Supplementary Table 1); Metabochip replication through proxy rs6845078 (r2 1, 15.6 kb away): C +0.0618 SD (SE 0.0074), P 8.18e-17, N 80,051 (Supplementary Table 3); 0.07 SD per copy (Supplementary Table 1)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 229 / 826 / 1449 · Africa 140 / 308 / 213 · The Americas 17 / 83 / 247 · East Asia 19 / 124 / 361 · Europe 7 / 113 / 383 · South Asia 46 / 198 / 245

See this card in the sample report

Limits

What it cannot tell you

A single marker, one of many hundreds that shape adult height.

Defining the role of common variation in the genomic and biological architecture of adult human height (Wood et al., 2014)

The same topic

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