Evidence · Replicated

What the research found

In the cited research, the G allele at rs724016 was associated with greater adult height in the studied cohorts.

AA: Lower average
AG: Middle
GG: Higher average

Slight effect

What the study found

In the study, each copy went with adult height about 0.31 cm higher on average.

European-ancestry adults in four validation panels (FINRISK97, KORA S4, PPP, FUSION stage 2) · Table 1 (follow-up columns; effects in centimetres per CEU minor allele G)Identification of ten loci associated with height highlights new biological pathways in human growth (Lettre et al., 2008)

Evidence: Genome-wide association with independent replication
Who was studied: European-ancestry adults

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	AALower average	AGMiddle	GGHigher average
All regions2,504 people	32%	40%	28%
Africa661 people	3%	29%	67%
The Americas347 people	35%	44%	20%
East Asia504 people	46%	42%	11%
Europe503 people	32%	50%	17%
South Asia489 people	53%	39%	8%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	36%19 of 53 copies read
First farmers6500 to 3000 BC	60%460 of 767 copies read
Bronze Age3000 to 1200 BC	58%350 of 600 copies read
Iron Age and Antiquity1200 BC to AD 600	44%359 of 823 copies read
Middle AgesAD 600 to 1500	41%200 of 485 copies read
Today1000 Genomes	42%426 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: 2 copies
Chagyrskaya Neanderthal: 2 copies
Denisovan: 1 copy

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs724016

The marker

Gene or region: ZBTB38
Marker: rs724016
Location: Chromosome 3 · GRCh37 141,105,570 · GRCh38 141,386,728
Letters studied: A and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: ZBTB38 · rs724016
Location: Chromosome 3 · GRCh37 141,105,570 · GRCh38 141,386,728
Studied allele: G
Published statistic: Lettre 2008 Table 1: follow-up 0.307 cm per G (SE 0.051), P 2.5e-11; GWA meta-analysis 0.461 cm (SE 0.070), P 5.0e-12, n 15,821; combined 0.365 cm (SE 0.038), P 8.3e-22. Wood 2014: A -0.0779 SD, P 3.24e-158, N 252,972; Metabochip replication A -0.0798 SD, P 4.69e-54, N 80,022 (Table 1 (follow-up columns; effects in centimetres per CEU minor allele G))
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 804 / 1003 / 697 · Africa 23 / 192 / 446 · The Americas 123 / 154 / 70 · East Asia 234 / 214 / 56 · Europe 163 / 254 / 86 · South Asia 261 / 189 / 39

See this card in the sample report

Limits

What it cannot tell you

A single marker, one of many hundreds that shape adult height.

Defining the role of common variation in the genomic and biological architecture of adult human height (Wood et al., 2014)

The same topic

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