DNA Traits · Body & performance
Handgrip strength association
How hard the hand can squeeze, a common measure of muscle strength.
What the research found
In the cited research, the A allele at rs10186876 was associated with higher maximal handgrip strength in the studied cohorts.
- GG
- Lower average
- AG
- Middle
- AA
- Higher average
What the study found
In the study, each copy went with maximal handgrip strength about 0.15 kg higher on average.
- Evidence
- Genome-wide association with nominal independent support
- Who was studied
- European-ancestry UK Biobank discovery and independent replication cohorts
How common each genotype is
| Region | GGLower average | AGMiddle | AAHigher average |
|---|---|---|---|
| All regions2,504 people | 15% | 34% | 51% |
| Africa661 people | 2% | 26% | 72% |
| The Americas347 people | 17% | 49% | 34% |
| East Asia504 people | Not seen | 8% | 92% |
| Europe503 people | 40% | 44% | 16% |
| South Asia489 people | 21% | 51% | 28% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- LRPPRC region
- Marker
- rs10186876
- Location
- Chromosome 2 · GRCh37 44,241,155 · GRCh38 44,014,016
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- LRPPRC region · rs10186876
- Location
- Chromosome 2 · GRCh37 44,241,155 · GRCh38 44,014,016
- Studied allele
- A
- Published statistic
- beta 0.147 kg per A allele (SE 0.023), P 9.8e-11, N 192,490 (combined); stage one 0.162 (SE 0.027), P 2.7e-9; stage two 0.113 (SE 0.041), P 6.2e-3, N 50,455 (Supplementary Table 2A); Table 1 (Table 1 (combined columns))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 379 / 850 / 1275 · Africa 11 / 173 / 477 · The Americas 60 / 170 / 117 · East Asia 0 / 39 / 465 · Europe 203 / 220 / 80 · South Asia 105 / 248 / 136
What it cannot tell you
The average association was small, about 0.15 kg per A allele. Handgrip is one measured form of strength; this marker cannot tell you your current grip, general athletic ability or response to strength training, and it is not a test for a muscle disorder. Only the studied A/G allele pair is interpreted. Independent follow-up supported the same direction at nominal P=0.0062, but did not pass a correction for the 21 markers followed up.
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness (Willems et al., 2017)More in Body & performance
- Lean body mass association
- Adult height association
- Body fat percentage association
- Waist-to-hip ratio association in women
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Handgrip strength (TGFA)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.