Evidence · Replicated

What the research found

In the cited research, the G allele at rs1812175 was associated with greater adult height in the studied cohorts.

AA: Lower average
AG: Middle
GG: Higher average

Slight effect

What the study found

In the study, each copy went with higher adult height on average.

European-ancestry adults in 37 independent Metabochip studies · 80,047 people · Supplementary Table 3

Evidence: Genome-wide association with independent replication
Who was studied: European-ancestry adults

1000 Genomes Project

How common each genotype is

How common each genotype is in the 1000 Genomes Project, by region
Region	AALower average	AGMiddle	GGHigher average
All regions2,504 people	8%	34%	58%
Africa661 people	10%	38%	51%
The Americas347 people	6%	32%	61%
East Asia504 people	16%	48%	37%
Europe503 people	3%	30%	66%
South Asia489 people	2%	18%	79%

Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.

Ancient genomes

Through time

How often the studied letter was read in ancient people, era by era, in the region chosen.

Region

Through time: Europe
Before farmingbefore 6500 BC	95%40 of 42 copies read
First farmers6500 to 3000 BC	77%359 of 466 copies read
Bronze Age3000 to 1200 BC	81%292 of 359 copies read
Iron Age and Antiquity1200 BC to AD 600	79%418 of 529 copies read
Middle AgesAD 600 to 1500	78%351 of 448 copies read
Today1000 Genomes	81%819 of 1,006 copies

Neanderthal and Denisovan genomes

Altai Neanderthal: 2 copies
Vindija Neanderthal: Not read
Chagyrskaya Neanderthal: Not read
Denisovan: 2 copies

Neanderthals and Denisovans carried this letter too: it is the older of the two.

For most ancient people only one of their two copies can be read, so these counts are copies read, not people. Close relatives, repeated samples and samples the archive marks as unreliable are left out. Damage in old DNA can fake this letter, so it is counted only from samples treated to remove that damage and from high-quality genomes. Ancient genomes from the Allen Ancient DNA Resource (AADR v66): 15,136 people.

rs1812175

The marker

Gene or region: HHIP
Marker: rs1812175
Location: Chromosome 4 · GRCh37 145,574,844 · GRCh38 144,653,692
Letters studied: A and G, with G as the studied allele

A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.

Marker: HHIP · rs1812175
Location: Chromosome 4 · GRCh37 145,574,844 · GRCh38 144,653,692
Studied allele: G
Published statistic: GWAS meta-analysis: A -0.0787 SD (SE 0.0040), P 2.07e-86, N 253,103, A frequency 0.163 (Supplementary Table 1); Metabochip replication: A -0.0857 SD (SE 0.0068), P 1.21e-36, N 80,047 (Supplementary Table 3); 0.09 SD per copy (Supplementary Table 3)
1000 Genomes Project phase 3, people with 0, 1 and 2 copies: All regions 199 / 849 / 1456 · Africa 69 / 254 / 338 · The Americas 22 / 112 / 213 · East Asia 79 / 240 / 185 · Europe 17 / 153 / 333 · South Asia 12 / 90 / 387

See this card in the sample report

Limits

What it cannot tell you

A single marker, one of many hundreds that shape adult height.

Defining the role of common variation in the genomic and biological architecture of adult human height (Wood et al., 2014)

The same topic

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