DNA Traits · Body & performance
Waist-to-hip ratio association in women
Waist size compared with hip size, which reflects where the body stores fat, in women.
What the research found
In the cited research, the G allele at rs4846567 was associated with a higher waist-to-hip ratio after adjustment for BMI in the studied women.
- TT
- Lower average
- GT
- Middle
- GG
- Higher average
What the study found
In the study, each copy went with higher waist-to-hip ratio adjusted for BMI on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry female discovery and follow-up cohorts
The research behind this card was done only in women, so it is part of a report requested as female.
How common each genotype is
| Region | TTLower average | GTMiddle | GGHigher average |
|---|---|---|---|
| All regions2,504 people | 8% | 29% | 63% |
| Africa661 people | <1% | 8% | 92% |
| The Americas347 people | 28% | 41% | 31% |
| East Asia504 people | 6% | 36% | 58% |
| Europe503 people | 8% | 41% | 51% |
| South Asia489 people | 5% | 30% | 65% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 71%76 of 107 copies read |
|---|---|
| First farmers6500 to 3000 BC | 80%878 of 1,097 copies read |
| Bronze Age3000 to 1200 BC | 78%798 of 1,020 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 75%1,286 of 1,717 copies read |
| Middle AgesAD 600 to 1500 | 71%1,090 of 1,535 copies read |
| Today1000 Genomes | 71%718 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- 2 copies
- Vindija Neanderthal
- 2 copies
- Chagyrskaya Neanderthal
- 2 copies
- Denisovan
- 2 copies
Neanderthals and Denisovans carried this letter too: it is the older of the two.
The marker
- Gene or region
- LYPLAL1 region
- Marker
- rs4846567
- Location
- Chromosome 1 · GRCh37 219,750,717 · GRCh38 219,577,375
- Letters studied
- G and T, with G as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- LYPLAL1 region · rs4846567
- Location
- Chromosome 1 · GRCh37 219,750,717 · GRCh38 219,577,375
- Studied allele
- G
- Published statistic
- Women: discovery 0.064 (P 4.84e-18), follow-up 0.055 (P 8.12e-17), combined 0.059 (P 4.95e-33); men combined 0.005 (P 0.358); sex difference P 1.18e-13; Table 2; 0.06 SD per copy (Table 2 (women, combined column))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 194 / 727 / 1583 · Africa 2 / 52 / 607 · The Americas 96 / 142 / 109 · East Asia 31 / 180 / 293 · Europe 42 / 204 / 257 · South Asia 23 / 149 / 317
What it cannot tell you
This association was strong in women and was not significant in men in the cited analysis. The outcome was waist-to-hip ratio adjusted for BMI; it cannot predict a body shape, waist size, visceral fat or metabolic risk, and it does not choose a diet or exercise plan.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (Heid et al., 2010)More in Body & performance
- Handgrip strength association
- Lean body mass association
- Adult height association
- Body fat percentage association
- Bone mineral density association
- Resting heart rate association
- Body mass index association
- Body mass index (MC4R)
- Adult height (GDF5)
- Adult height (ZBTB38)
- Adult height (HHIP)
- Adult height (LCORL)
- Waist-to-hip ratio in women (GRB14)
- Waist-to-hip ratio in women (ADAMTS9)
- Bone mineral density (WNT16)
- Bone mineral density (BMP4)
- Bone mineral density (CYP24A1)
- Handgrip strength (TGFA)
- Lean body mass (ADAMTSL3)
- Resting heart rate (GJA1)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.