DNA Traits · Sleep & rhythms
Daytime napping association
How often people nap during the day.
What the research found
In the cited research, the A allele at rs2653349 was associated with more frequent self-reported daytime napping in the studied cohorts.
- GG
- Less often
- AG
- Middle
- AA
- More often
What the study found
In the study, each copy went with how often people nap, on a three-step scale from never or rarely to usually about 0.02 points higher on average.
- Evidence
- Genome-wide association with independent replication
- Who was studied
- European-ancestry UK Biobank discovery and independent 23andMe replication participants
How common each genotype is
| Region | GGLess often | AGMiddle | AAMore often |
|---|---|---|---|
| All regions2,504 people | 78% | 21% | 2% |
| Africa661 people | 80% | 19% | 1% |
| The Americas347 people | 78% | 20% | 2% |
| East Asia504 people | 88% | 12% | <1% |
| Europe503 people | 67% | 30% | 4% |
| South Asia489 people | 75% | 22% | 2% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
Through time
How often the studied letter was read in ancient people, era by era, in the region chosen.
| Before farmingbefore 6500 BC | 6%4 of 63 copies read |
|---|---|
| First farmers6500 to 3000 BC | 15%140 of 948 copies read |
| Bronze Age3000 to 1200 BC | 22%203 of 934 copies read |
| Iron Age and Antiquity1200 BC to AD 600 | 18%198 of 1,110 copies read |
| Middle AgesAD 600 to 1500 | 16%94 of 590 copies read |
| Today1000 Genomes | 18%185 of 1,006 copies |
Neanderthal and Denisovan genomes
- Altai Neanderthal
- No copies
- Vindija Neanderthal
- No copies
- Chagyrskaya Neanderthal
- No copies
- Denisovan
- No copies
Neanderthals and Denisovans carried the other letter, so this letter is younger than our split with them.
The marker
- Gene or region
- HCRTR2
- Marker
- rs2653349
- Location
- Chromosome 6 · GRCh37 55,142,337 · GRCh38 55,277,539
- Letters studied
- A and G, with A as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- HCRTR2 · rs2653349
- Location
- Chromosome 6 · GRCh37 55,142,337 · GRCh38 55,277,539
- Studied allele
- A
- Published statistic
- Meta-analysis beta 0.0161 per A (SE 0.0011), P 5.87e-52, n 993,966; independent 23andMe replication 0.0156 (SE 0.0015), P 3.0e-25, n 541,333; UK Biobank 0.0166 (SE 0.0015), P 3.4e-29, n 452,633; A frequency 0.21 (Supplementary Data 2)
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1943 / 515 / 46 · Africa 527 / 126 / 8 · The Americas 269 / 70 / 8 · East Asia 442 / 61 / 1 · Europe 336 / 149 / 18 · South Asia 369 / 109 / 11
What it cannot tell you
This is a small association with reported nap frequency, not a prediction of how often you nap or whether naps help you. It is not a test for a sleep disorder and says nothing about heart disease. Only the studied A/G allele pair is interpreted; C/T calls are unsupported by this association.
Genetic determinants of daytime napping and effects on cardiometabolic health (Dashti et al., 2021)More in Sleep & rhythms
- Morning preference association
- Snoring tendency association
- Sleep efficiency association
- Overnight sleep episodes association
- Sleep midpoint timing association
- Daytime sleepiness association
- Difficulty sleeping association
- Morning preference (RGS16)
- Morning preference (AK5)
- Snoring (POC5)
- Snoring (TRAM1)
- Daytime napping (TLE4)
- Daytime napping (STK32A)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.