DNA Traits · Sleep & rhythms
Sleep midpoint timing association
The clock time halfway through a night of sleep, measured with a wrist tracker.
What the research found
In the cited research, the T allele at rs11892220 was associated with later accelerometer-estimated sleep midpoint timing in the studied cohorts.
- AA
- Earlier
- AT
- Middle
- TT
- Later
What the study found
In the study, each copy went with higher lateness of the sleep midpoint, the clock time halfway through the night's sleep, from a wrist tracker on average.
- Evidence
- Suggestive association in an accelerometer GWAS
- Who was studied
- European-ancestry UK Biobank adults with seven-day wrist accelerometer measurements
How common each genotype is
| Region | AAEarlier | ATMiddle | TTLater |
|---|---|---|---|
| All regions2,504 people | 61% | 32% | 7% |
| Africa661 people | 80% | 19% | 1% |
| The Americas347 people | 57% | 35% | 8% |
| East Asia504 people | 65% | 30% | 4% |
| Europe503 people | 49% | 41% | 11% |
| South Asia489 people | 46% | 42% | 12% |
Among the 2,504 people of the 1000 Genomes Project, in five world regions. These percentages describe groups of people, never anyone’s chance of having a trait.
The marker
- Gene or region
- CAB39 region
- Marker
- rs11892220
- Location
- Chromosome 2 · GRCh37 231,691,067 · GRCh38 230,826,352
- Letters studied
- A and T, with T as the studied allele
A DNA Traits report reads this marker in your raw DNA file and shows which of the three genotypes is yours, with how common it is. It counts the copies of the studied allele; it does not measure the trait itself.
- Marker
- CAB39 region · rs11892220
- Location
- Chromosome 2 · GRCh37 231,691,067 · GRCh38 230,826,352
- Studied allele
- T
- Published statistic
- beta 0.029 SD per T allele (SE 0.005), P 3e-8; T frequency 0.339; met 5e-8 but not the study's 8e-10 multiple-trait threshold; 0.03 SD per copy (Table 3 (beta, SE, P, effect allele frequency); Methods, association testing paragraph (results reported on the inverse-normal scale))
- 1000 Genomes Project phase 3, people with 0, 1 and 2 copies
- All regions 1524 / 809 / 171 · Africa 526 / 128 / 7 · The Americas 199 / 120 / 28 · East Asia 329 / 153 / 22 · Europe 244 / 205 / 54 · South Asia 226 / 203 / 60
What it cannot tell you
Sleep midpoint is the midpoint between estimated sleep onset and waking. This signal met the usual genome-wide threshold but not the study’s stricter multiple-trait threshold. This device-based timing association is distinct from self-reported morning preference, although sleep-timing traits are related. It does not predict your bedtime, waking time or ideal schedule. Only the studied A/T allele pair is interpreted.
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour (Jones et al., 2019)More in Sleep & rhythms
- Morning preference association
- Snoring tendency association
- Sleep efficiency association
- Overnight sleep episodes association
- Daytime napping association
- Daytime sleepiness association
- Difficulty sleeping association
- Morning preference (RGS16)
- Morning preference (AK5)
- Snoring (POC5)
- Snoring (TRAM1)
- Daytime napping (TLE4)
- Daytime napping (STK32A)
See your own two letters.
Upload the raw DNA file you already have. Your report reads this marker and every other card studied for you, each with its evidence and its limits.